Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TLR4 | O00206 | 3/20 | 0.48 |
| ▸ | TLR2 | O60603 | 3/20 | 0.48 |
| ▸ | MAPT | P10636 | 7/20 | 0.47 |
| ▸ | RAB9A | P51151 | 6/20 | 0.42 |
| ▸ | NPC1 | O15118 | 5/20 | 0.42 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.42 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.42 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.42 |
| ▸ | RELA | Q04206 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.42 |
| ▸ | MEN1 | O00255 | 3/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.42 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.42 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.41 |
| ▸ | RHOA | P61586 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.40 |
| ▸ | EGFR | P00533 | 2/20 | 0.39 |
| ▸ | LCK | P06239 | 1/20 | 0.38 |
| ▸ | LYN | P07948 | 1/20 | 0.38 |
| ▸ | SRC | P12931 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7358953 | 1.00 | TLR4 (0.48) | TLR4TLR2MAPTRAB9ANPC1 | |
| SCHEMBL6796960 | 0.90 | TLR4 (0.53) | TLR4TLR2MAPTRAB9ANPC1 | |
| SCHEMBL6796952 | 0.90 | TLR4 (0.53) | TLR4TLR2MAPTRAB9ANPC1 | |
| SCHEMBL7362392 | 0.89 | MAPT (0.48) | TLR4TLR2MAPTRAB9ANPC1 | |
| SCHEMBL7493488 | 0.89 | MAPT (0.48) | TLR4TLR2MAPTRAB9ANPC1 | |
| SCHEMBL6798714 | 0.87 | TLR4 (0.51) | TLR4TLR2MAPTRAB9ANPC1 | |
| SCHEMBL6798711 | 0.87 | TLR4 (0.51) | TLR4TLR2MAPTRAB9ANPC1 | |
| SCHEMBL6802207 | 0.84 | RAB9A (0.58) | TLR4TLR2MAPTRAB9ANPC1 | |
| SCHEMBL6802212 | 0.84 | RAB9A (0.58) | TLR4TLR2MAPTRAB9ANPC1 | |
| SCHEMBL6794718 | 0.84 | TLR4 (0.57) | TLR4TLR2MAPTRAB9ANPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0874845-B1 | PYRIDO (2,3-B) PYRAZINE DERIVATIVES | FUJISAWA PHARMACEUTICAL CO (JP) | 2002-03-06 | — | — | EP | disclosed |
| US-6117875-A | Pyrido (2,3-B) pyrazine derivatives | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 2000-09-12 | — | — | US | disclosed |