Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 7/20 | 0.54 |
| ▸ | MEN1 | O00255 | 5/20 | 0.54 |
| ▸ | CXCR1 | P25024 | 2/20 | 0.54 |
| ▸ | CXCR2 | P25025 | 2/20 | 0.54 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.54 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.54 |
| ▸ | MAPK14 | Q16539 | 3/20 | 0.48 |
| ▸ | MAPT | P10636 | 6/20 | 0.47 |
| ▸ | NPC1 | O15118 | 1/20 | 0.47 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.47 |
| ▸ | RAB9A | P51151 | 1/20 | 0.47 |
| ▸ | LMNA | P02545 | 2/20 | 0.45 |
| ▸ | HTT | P42858 | 1/20 | 0.45 |
| ▸ | RORC | P51449 | 1/20 | 0.45 |
| ▸ | KCNMA1 | Q12791 | 1/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.44 |
| ▸ | GAA | P10253 | 2/20 | 0.44 |
| ▸ | POLB | P06746 | 1/20 | 0.43 |
| ▸ | DDX3X | O00571 | 1/20 | 0.43 |
| ▸ | TRPV1 | Q8NER1 | 2/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3706043 | 0.89 | CXCR1 (0.61) | KMT2AMEN1CXCR1CXCR2TDP1 | |
| SCHEMBL3711422 | 0.88 | CXCR2 (0.67) | KMT2AMEN1CXCR1CXCR2TDP1 | |
| SCHEMBL6820181 | 0.82 | KMT2A (0.59) | KMT2AMEN1CXCR1CXCR2TDP1 | |
| SCHEMBL7490940 | 0.81 | MAPT (0.68) | KMT2AMEN1CXCR1CXCR2TDP1 | |
| SCHEMBL3716989 | 0.80 | CXCR2 (0.64) | KMT2AMEN1CXCR1CXCR2TDP1 | |
| SCHEMBL7490611 | 0.80 | MEN1 (0.52) | KMT2AMEN1CXCR1CXCR2TDP1 | |
| SCHEMBL3706835 | 0.79 | KMT2A (0.74) | KMT2AMEN1CXCR1CXCR2TDP1 | |
| SCHEMBL6825964 | 0.78 | KMT2A (0.56) | KMT2AMEN1CXCR1CXCR2TDP1 | |
| SCHEMBL5595057 | 0.77 | CXCR1 (0.60) | KMT2AMEN1CXCR1CXCR2TDP1 | |
| SCHEMBL3707203 | 0.76 | KMT2A (0.60) | KMT2AMEN1CXCR1CXCR2TDP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0896531-A4 | IL-8 RECEPTOR ANTAGONISTS | SMITHKLINE BEECHAM CORP (US) | 2002-10-30 | — | — | EP | disclosed |
| EP-0896531-A1 | IL-8 RECEPTOR ANTAGONISTS | SMITHKLINE BEECHAM CORPORATION (US) | 1999-02-17 | — | — | EP | disclosed |
| WO-1997029743-A1 | IL-8 RECEPTOR ANTAGONISTS | SMITHKLINE BEECHAM CORPORATION (US) | 1997-08-21 | — | — | WO | disclosed |