Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CXCR2 | P25025 | 12/20 | 0.66 |
| ▸ | CXCR1 | P25024 | 8/20 | 0.66 |
| ▸ | MEN1 | O00255 | 4/20 | 0.66 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.66 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.66 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.66 |
| ▸ | MAPT | P10636 | 4/20 | 0.56 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.56 |
| ▸ | LMNA | P02545 | 1/20 | 0.56 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.56 |
| ▸ | NPC1 | O15118 | 1/20 | 0.45 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.45 |
| ▸ | RAB9A | P51151 | 1/20 | 0.45 |
| ▸ | PYGL | P06737 | 1/20 | 0.42 |
| ▸ | PYGM | P11217 | 1/20 | 0.42 |
| ▸ | RORC | P51449 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7491012 | 0.88 | CXCR2 (0.70) | CXCR2CXCR1MEN1KMT2ATDP1 | |
| SCHEMBL3708973 | 0.87 | CXCR1 (0.67) | CXCR2CXCR1MEN1KMT2ATDP1 | |
| SCHEMBL5595225 | 0.81 | MEN1 (0.60) | CXCR2CXCR1MEN1KMT2ATDP1 | |
| SCHEMBL29733649 | 0.81 | CXCR2 (1.00) | CXCR2CXCR1MEN1KMT2ATDP1 | |
| SCHEMBL29493172 | 0.81 | CXCR2 (1.00) | CXCR2CXCR1MEN1KMT2ATDP1 | |
| SCHEMBL1110610 | 0.81 | CXCR2 (1.00) | CXCR2CXCR1MEN1KMT2ATDP1 | |
| SCHEMBL6921874 | 0.81 | CXCR2 (1.00) | CXCR2CXCR1MEN1KMT2ATDP1 | |
| SCHEMBL7622098 | 0.76 | MAPT (0.61) | MEN1KMT2ATDP1MAPTALDH1A1 | |
| SCHEMBL3706835 | 0.76 | KMT2A (0.74) | CXCR2CXCR1MEN1KMT2ATDP1 | |
| SCHEMBL7493083 | 0.76 | CXCR2 (0.74) | CXCR2CXCR1MEN1KMT2ATDP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0896531-A4 | IL-8 RECEPTOR ANTAGONISTS | SMITHKLINE BEECHAM CORP (US) | 2002-10-30 | — | — | EP | disclosed |
| EP-0896531-A1 | IL-8 RECEPTOR ANTAGONISTS | SMITHKLINE BEECHAM CORPORATION (US) | 1999-02-17 | — | — | EP | disclosed |
| WO-1997029743-A1 | IL-8 RECEPTOR ANTAGONISTS | SMITHKLINE BEECHAM CORPORATION (US) | 1997-08-21 | — | — | WO | disclosed |