Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AXL | P30530 | 3/20 | 0.71 |
| ▸ | PDGFRA | P16234 | 15/20 | 0.69 |
| ▸ | KDR | P35968 | 12/20 | 0.69 |
| ▸ | KIT | P10721 | 3/20 | 0.66 |
| ▸ | MET | P08581 | 2/20 | 0.62 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2748000 | 0.92 | MET (0.71) | AXLPDGFRAKDRMET | |
| SCHEMBL5825719 | 0.91 | PDGFRA (0.75) | AXLPDGFRAKDRKITMET | |
| SCHEMBL4548865 | 0.91 | MET (0.69) | AXLPDGFRAKDRMET | |
| SCHEMBL4223563 | 0.84 | PDGFRA (0.81) | AXLPDGFRAKDRKITMET | |
| SCHEMBL7485920 | 0.84 | FGFR2 (0.61) | AXLPDGFRAKDRKIT | |
| SCHEMBL29973354 | 0.84 | PDGFRA (0.95) | PDGFRAKDR | |
| SCHEMBL27081475 | 0.84 | PDGFRA (0.95) | PDGFRAKDR | |
| SCHEMBL30918281 | 0.84 | PDGFRA (0.82) | AXLPDGFRAKDRKITMET | |
| SCHEMBL27082957 | 0.84 | PDGFRA (0.82) | AXLPDGFRAKDRKITMET | |
| SCHEMBL7475815 | 0.83 | AXL (1.00) | AXLPDGFRAKDRKIT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2609091-B1 | PHARMACEUTICALLY ACTIVE COMPOUNDS AS AXL INHIBITORS | LEAD DISCOVERY CENTER GMBH (DE) | 2014-11-26 | — | — | EP | disclosed |
| EP-0860433-B1 | QUINOLINE DERIVATIVES AND QUINAZOLINE DERIVATIVES INHIBITING AUTOPHOSPHORYLATION OF GROWTH FACTOR RECEPTOR ORIGINATING IN PLATELET AND PHARMACEUTICAL COMPOSITIONS CONTAINING THE SAME | KIRIN BREWERY (JP) | 2002-07-03 | — | — | EP | disclosed |
| US-6143764-A | ETHER DERIVATIVES OF QUINOLINE, ANTITUMOR AGENTS | KIRIN BEER KABUSHIKI KAISHA (JP) | 2000-11-07 | — | — | US | disclosed |
| EP-0860433-A1 | QUINOLINE DERIVATIVES AND QUINAZOLINE DERIVATIVES INHIBITING AUTOPHOSPHORYLATION OF GROWTH FACTOR RECEPTOR ORIGINATING IN PLATELET AND PHARMACEUTICAL COMPOSITIONS CONTAINING THE SAME | KIRIN BEER KABUSHIKI KAISHA (JP) | 1998-08-26 | — | — | EP | disclosed |