Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNH2 | Q12809 | 11/20 | 0.59 |
| ▸ | NR4A2 | P43354 | 2/20 | 0.59 |
| ▸ | SSTR5 | P35346 | 4/20 | 0.42 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.41 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | MLNR | O43193 | 1/20 | 0.41 |
| ▸ | CACNA1F | O60840 | 1/20 | 0.41 |
| ▸ | EED | O75530 | 1/20 | 0.41 |
| ▸ | USP2 | O75604 | 1/20 | 0.41 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.41 |
| ▸ | EGFR | P00533 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | HLA-A | P04439 | 1/20 | 0.41 |
| ▸ | ERBB2 | P04626 | 1/20 | 0.41 |
| ▸ | TP53 | P04637 | 1/20 | 0.41 |
| ▸ | LCK | P06239 | 1/20 | 0.41 |
| ▸ | FYN | P06241 | 1/20 | 0.41 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.41 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL7985497 | 0.86 | KCNH2 (0.60) | KCNH2NR4A2SSTR5CYP1A2CYP2C19 | |
| SCHEMBL6991613 | 0.86 | KCNH2 (0.59) | KCNH2NR4A2MEN1CHRM1HRH1 | |
| SCHEMBL9536919 | 0.85 | KCNH2 (0.58) | KCNH2NR4A2SSTR5MEN1HRH1 | |
| SCHEMBL13319057 | 0.85 | KCNH2 (0.63) | KCNH2NR4A2SSTR5CYP1A2CYP2C19 | |
| SCHEMBL7494343 | 0.83 | KCNH2 (0.67) | KCNH2NR4A2SSTR5CYP1A2CYP2C19 | |
| SCHEMBL7980989 | 0.81 | KCNH2 (0.58) | KCNH2NR4A2SSTR5CYP1A2CYP2C19 | |
| SCHEMBL7985049 | 0.80 | KCNH2 (0.65) | KCNH2NR4A2SSTR5 | |
| Oxalic Acid SCHEMBL10384126 | 0.78 | KCNH2 (0.50) | KCNH2NR4A2MEN1LMNAHRH1 | |
| Oxalic Acid SCHEMBL10384125 | 0.78 | KCNH2 (0.50) | KCNH2NR4A2MEN1LMNAHRH1 | |
| SCHEMBL7471446 | 0.78 | HRH1 (0.42) | MAPTTACR2TACR1HRH1SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0888336-B1 | NOVEL SUBSTITUTED N-METHYL-N-(4-(4-(1H-BENZIMIDAZOL-2-YL-AMINO)P IPERIDIN-1-YL)-2-(ARYL)BUTYL)BENZAMIDES USEFUL FOR THE TREATMENT OF ALLERGIC DISEASES | AVENTIS PHARMA INC (US) | 2002-08-07 | — | — | EP | disclosed |
| US-6211199-B1 | HISTAMINE AND TACHYKININ RECEPTOR ANTAGONISTS; ANTIASTHMATICS, ANTIEMETICS; RESPIRATORY SYSTEM DISORDERS, INFLAMMATORY BOWEL DISEASE, CONJUNCTIVITIS | AVENTIS PHARMACEUTICALS INC. | 2001-04-03 | — | — | US | disclosed |
| US-5922737-A | Substituted N-methyl-N-(4-(4-(1H-Benzimidazol-2-YL-amino) piperidin-1-YL)-2-(arlyl) butyl) benzamides useful for the treatment of allergic diseases | HOECHST MARION ROUSSEL, INC. (US) | 1999-07-13 | — | — | US | disclosed |