Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNH2 | Q12809 | 9/20 | 0.58 |
| ▸ | NR4A2 | P43354 | 1/20 | 0.58 |
| ▸ | SSTR5 | P35346 | 4/20 | 0.42 |
| ▸ | IRAK4 | Q9NWZ3 | 1/20 | 0.42 |
| ▸ | GAA | P10253 | 2/20 | 0.42 |
| ▸ | MAPT | P10636 | 2/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | MLNR | O43193 | 1/20 | 0.42 |
| ▸ | CACNA1F | O60840 | 1/20 | 0.42 |
| ▸ | EED | O75530 | 1/20 | 0.42 |
| ▸ | USP2 | O75604 | 1/20 | 0.42 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.42 |
| ▸ | EGFR | P00533 | 1/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
| ▸ | HLA-A | P04439 | 1/20 | 0.42 |
| ▸ | ERBB2 | P04626 | 1/20 | 0.42 |
| ▸ | TP53 | P04637 | 1/20 | 0.42 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.42 |
| ▸ | LCK | P06239 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6991613 | 0.86 | KCNH2 (0.59) | KCNH2NR4A2MEN1CHRM1HRH1 | |
| SCHEMBL9536919 | 0.83 | KCNH2 (0.58) | KCNH2NR4A2SSTR5SMN1; SMN2MEN1 | |
| Hydrochloric Acid SCHEMBL7985497 | 0.82 | KCNH2 (0.60) | KCNH2NR4A2SSTR5GAAMAPT | |
| SCHEMBL7985049 | 0.82 | KCNH2 (0.65) | KCNH2NR4A2SSTR5IRAK4MKNK1 | |
| SCHEMBL9534952 | 0.81 | KCNH2 (0.61) | KCNH2NR4A2SSTR5MAPTUSP2 | |
| SCHEMBL7492402 | 0.81 | KCNH2 (0.59) | KCNH2NR4A2SSTR5GAAMAPT | |
| SCHEMBL7988149 | 0.79 | ALDH1A1 (0.48) | KCNH2GAAMAPTSMN1; SMN2LMNA | |
| SCHEMBL7981124 | 0.79 | KCNH2 (0.61) | KCNH2NR4A2SSTR5IRAK4MAPT | |
| SCHEMBL6992893 | 0.78 | KCNH2 (0.59) | KCNH2NR4A2IRAK4MAPTSMN1; SMN2 | |
| SCHEMBL5537223 | 0.78 | KCNH2 (0.58) | KCNH2NR4A2SSTR5IRAK4GAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6211199-B1 | HISTAMINE AND TACHYKININ RECEPTOR ANTAGONISTS; ANTIASTHMATICS, ANTIEMETICS; RESPIRATORY SYSTEM DISORDERS, INFLAMMATORY BOWEL DISEASE, CONJUNCTIVITIS | AVENTIS PHARMACEUTICALS INC. | 2001-04-03 | — | — | US | disclosed |