Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 4/20 | 0.52 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.52 |
| ▸ | HPGD | P15428 | 1/20 | 0.52 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.52 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.52 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.52 |
| ▸ | NHERF1 | O14745 | 1/20 | 0.51 |
| ▸ | SMN1; SMN2 | Q16637 | 8/20 | 0.51 |
| ▸ | LMNA | P02545 | 3/20 | 0.51 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.47 |
| ▸ | MGAT2 | Q10469 | 3/20 | 0.47 |
| ▸ | BRD4 | O60885 | 1/20 | 0.47 |
| ▸ | MGAT1 | P26572 | 1/20 | 0.47 |
| ▸ | MGAT3 | Q09327 | 1/20 | 0.47 |
| ▸ | MAPT | P10636 | 1/20 | 0.47 |
| ▸ | TSHR | P16473 | 1/20 | 0.47 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.47 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.46 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7493373 | 1.00 | MEN1 (0.52) | MEN1KMT2AALDH1A1HPGDALOX15 | |
| SCHEMBL7499109 | 0.88 | MAPT (0.52) | MEN1KMT2AALDH1A1MAPK1SMN1; SMN2 | |
| SCHEMBL7499102 | 0.88 | MAPT (0.52) | MEN1KMT2AALDH1A1MAPK1SMN1; SMN2 | |
| SCHEMBL7490795 | 0.87 | MEN1 (0.56) | MEN1KMT2AMAPK1HSD17B10SMN1; SMN2 | |
| SCHEMBL7485899 | 0.87 | BRD4 (0.53) | MEN1KMT2AMAPK1SMN1; SMN2LMNA | |
| SCHEMBL7490799 | 0.87 | MEN1 (0.56) | MEN1KMT2AMAPK1HSD17B10SMN1; SMN2 | |
| SCHEMBL7485892 | 0.87 | BRD4 (0.53) | MEN1KMT2AMAPK1SMN1; SMN2LMNA | |
| SCHEMBL7488835 | 0.87 | MGAT2 (0.55) | MEN1KMT2AMAPK1SMN1; SMN2MGAT2 | |
| SCHEMBL7497322 | 0.87 | MGAT2 (0.55) | MEN1KMT2AMAPK1SMN1; SMN2MGAT2 | |
| SCHEMBL7493713 | 0.86 | BRD4 (0.55) | MEN1KMT2AALDH1A1LMNAMGAT2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1224169-A2 | PRODUCTION OF 5-SUBSTITUTED INDOLINONES AND USE THEREOF AS MEDICAMENTS | Boehringer Ingelheim Pharma KG (DE) | 2002-07-24 | — | — | EP | disclosed |
| WO-2001027080-A2 | 5-SUBSTITUTED INDOLINONES AND USE THEREOF AS KINASE AND CYCLIN/CDK COMPLEX INHIBITORS | BOEHRINGER INGELHEIM PHARMA KG (DE) | 2001-04-19 | — | — | WO | disclosed |