Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PSMB5 | P28074 | 5/20 | 0.42 |
| ▸ | REN | P00797 | 9/20 | 0.38 |
| ▸ | PSEN1 | P49768 | 3/20 | 0.38 |
| ▸ | PSEN2 | P49810 | 3/20 | 0.38 |
| ▸ | APH1B | Q8WW43 | 3/20 | 0.38 |
| ▸ | NCSTN | Q92542 | 3/20 | 0.38 |
| ▸ | APH1A | Q96BI3 | 3/20 | 0.38 |
| ▸ | PSENEN | Q9NZ42 | 3/20 | 0.38 |
| ▸ | CTSD | P07339 | 2/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7432319 | 0.91 | PSMB5 (0.40) | PSMB5RENPSEN1PSEN2APH1B | |
| SCHEMBL7431811 | 0.90 | PSMB5 (0.41) | PSMB5RENPSEN1PSEN2APH1B | |
| SCHEMBL10520747 | 0.88 | PSMB5 (0.42) | PSMB5RENPSEN1PSEN2APH1B | |
| SCHEMBL10522879 | 0.82 | PSMB5 (0.38) | PSMB5RENPSEN1PSEN2APH1B | |
| SCHEMBL7435175 | 0.81 | PSMB5 (0.41) | PSMB5RENPSEN1PSEN2APH1B | |
| SCHEMBL7433145 | 0.80 | REN (0.44) | REN | |
| SCHEMBL7431999 | 0.78 | REN (0.39) | PSMB5RENCTSD | |
| SCHEMBL9574983 | 0.77 | REN (0.46) | REN | |
| SCHEMBL7428042 | 0.76 | REN (0.36) | RENCTSD | |
| SCHEMBL10522535 | 0.76 | REN (0.45) | REN |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-1989007940-A1 | 1,2-HYDROXY PHOSPHONATES AND DERIVATIVES THEREOF | E.R. SQUIBB & SONS, INC. (US) | 1989-09-08 | — | — | WO | claimed |
| EP-0331105-A2 | 1,2-Hydroxy phosphonates and derivatives thereof | E.R. Squibb & Sons, Inc. (US) | 1989-09-06 | — | — | EP | claimed |
| US-5217958-A | Hypotensive agents | E. R. SQUIBB & SONS, INC. (US) | 1993-06-08 | — | — | US | disclosed |
| WO-1989007940-A1 | 1,2-HYDROXY PHOSPHONATES AND DERIVATIVES THEREOF | E.R. SQUIBB & SONS, INC. (US) | 1989-09-08 | — | — | WO | disclosed |