Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HAVCR2 | Q8TDQ0 | 1/20 | 0.72 |
| ▸ | TSHR | P16473 | 1/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.44 |
| ▸ | MEN1 | O00255 | 3/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.43 |
| ▸ | PIM1 | P11309 | 2/20 | 0.42 |
| ▸ | AURKA | O14965 | 1/20 | 0.42 |
| ▸ | DAPK3 | O43293 | 1/20 | 0.42 |
| ▸ | JAK2 | O60674 | 1/20 | 0.42 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.42 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.42 |
| ▸ | PAK4 | O96013 | 1/20 | 0.42 |
| ▸ | ABL1 | P00519 | 1/20 | 0.42 |
| ▸ | CSF1R | P07333 | 1/20 | 0.42 |
| ▸ | RET | P07949 | 1/20 | 0.42 |
| ▸ | IGF1R | P08069 | 1/20 | 0.42 |
| ▸ | MET | P08581 | 1/20 | 0.42 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.42 |
| ▸ | PARP1 | P09874 | 1/20 | 0.42 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11867822 | 0.85 | HAVCR2 (0.70) | HAVCR2TSHRALDH1A1MEN1KMT2A | |
| SCHEMBL2717720 | 0.85 | HAVCR2 (0.57) | HAVCR2TSHRMEN1KMT2APIM1 | |
| SCHEMBL20138998 | 0.84 | HAVCR2 (0.52) | HAVCR2TSHRALDH1A1MEN1KMT2A | |
| SCHEMBL2719152 | 0.84 | HAVCR2 (0.52) | HAVCR2TSHRMEN1KMT2AAURKA | |
| SCHEMBL7494879 | 0.84 | HAVCR2 (0.52) | HAVCR2TSHRALDH1A1MEN1KMT2A | |
| Hydrochloric Acid SCHEMBL11869520 | 0.84 | HAVCR2 (0.68) | HAVCR2TSHRALDH1A1MEN1KMT2A | |
| SCHEMBL436716 | 0.84 | HAVCR2 (1.00) | HAVCR2TSHRALDH1A1MEN1KMT2A | |
| SCHEMBL8476104 | 0.81 | HAVCR2 (0.50) | HAVCR2MEN1KMT2AJAK2MAPT | |
| SCHEMBL1257667 | 0.80 | MEN1 (0.51) | HAVCR2MEN1KMT2A | |
| SCHEMBL528848 | 0.80 | HAVCR2 (0.49) | HAVCR2TSHRALDH1A1MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-101300236-A | Triazole compounds as lipoxygenase inhibitors | BIOLIPOX AB (SE) | 2008-11-05 | — | — | CN | disclosed |
| CN-1097459-C | Diazepino-indoles as phosphodiesterase IV inhibitors | JOUVEINAL INST RECH (FR) | 2003-01-01 | — | — | CN | disclosed |
| EP-0785789-B1 | DIAZEPINO-INDOLES AS PHOSPHODIESTERASE IV INHIBITORS | PFIZER (FR) | 2002-09-11 | — | — | EP | disclosed |
| CN-1160352-A | Diaza * -oxindoles as phosphodiesterase IV inhibitors | JOUVEINAL INST RECH (FR) | 1997-09-24 | — | — | CN | disclosed |
| EP-0785789-A1 | DIAZEPINO-INDOLES AS PHOSPHODIESTERASE IV INHIBITORS | INSTITUT DE RECHERCHE JOUVEINAL (I.R.J) (FR) | 1997-07-30 | — | — | EP | disclosed |
| WO-1996011690-A1 | DIAZEPINO-INDOLES AS PHOSPHODIESTERASE IV INHIBITORS | INSTITUT DE RECHERCHE JOUVEINAL (FR) | 1996-04-25 | — | — | WO | disclosed |