Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ROCK1 | Q13464 | 1/20 | 0.44 |
| ▸ | MAP3K14 | Q99558 | 4/20 | 0.41 |
| ▸ | MKNK1 | Q9BUB5 | 4/20 | 0.41 |
| ▸ | LCK | P06239 | 7/20 | 0.40 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.40 |
| ▸ | RPS6KA5 | O75582 | 1/20 | 0.40 |
| ▸ | MKNK2 | Q9HBH9 | 3/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | GAA | P10253 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
| ▸ | CDK2 | P24941 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7018051 | 0.84 | LCK (0.55) | ROCK1MAP3K14LCKFGFR1RPS6KA5 | |
| SCHEMBL7024738 | 0.83 | ROCK1 (0.62) | ROCK1MKNK1LCKRPS6KA5MKNK2 | |
| SCHEMBL7492144 | 0.82 | ROCK1 (0.39) | ROCK1MAP3K14MKNK1LCKFGFR1 | |
| SCHEMBL7498487 | 0.81 | LCK (0.57) | ROCK1MAP3K14MKNK1LCKFGFR1 | |
| SCHEMBL7021644 | 0.81 | MAP3K14 (0.39) | ROCK1MAP3K14MKNK1LCKFGFR1 | |
| SCHEMBL7027073 | 0.80 | FGFR1 (0.54) | MKNK1LCKFGFR1MKNK2ALDH1A1 | |
| SCHEMBL7024457 | 0.79 | LCK (0.55) | ROCK1MAP3K14LCK | |
| SCHEMBL7016970 | 0.78 | MKNK1 (0.52) | ROCK1MAP3K14MKNK1LCKFGFR1 | |
| SCHEMBL7021439 | 0.78 | JAK2 (0.53) | ROCK1MAP3K14MKNK1RPS6KA5MKNK2 | |
| SCHEMBL7496738 | 0.77 | LCK (0.46) | ROCK1MAP3K14LCKFGFR1RPS6KA5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1194152-A4 | SRC KINASE INHIBITOR COMPOUNDS | MERCK & CO INC (US) | 2002-11-06 | — | — | EP | disclosed |
| EP-1194152-A1 | SRC KINASE INHIBITOR COMPOUNDS | Merck & Co., Inc. (US) | 2002-04-10 | — | — | EP | disclosed |
| US-6316444-B1 | SRC kinase inhibitor compounds | MERCK & CO., INC. | 2001-11-13 | — | — | US | disclosed |
| WO-2001000214-A1 | SRC KINASE INHIBITOR COMPOUNDS | MERCK & CO., INC. (US) | 2001-01-04 | — | — | WO | disclosed |