Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LCK | P06239 | 6/20 | 0.57 |
| ▸ | MKNK1 | Q9BUB5 | 5/20 | 0.41 |
| ▸ | KDR | P35968 | 1/20 | 0.40 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 2/20 | 0.38 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.38 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.38 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.38 |
| ▸ | THRB | P10828 | 1/20 | 0.38 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.38 |
| ▸ | HTT | P42858 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.38 |
| ▸ | MKNK2 | Q9HBH9 | 3/20 | 0.38 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.38 |
| ▸ | MAP3K14 | Q99558 | 2/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7019434 | 0.82 | LCK (0.49) | LCKMKNK1KDRCYP3A4CYP2D6 | |
| SCHEMBL7496738 | 0.81 | LCK (0.46) | LCKROCK1MAPTCYP2C9CYP1A2 | |
| SCHEMBL7018051 | 0.81 | LCK (0.55) | LCKROCK1MAPTFGFR1MAP3K14 | |
| SCHEMBL7494174 | 0.81 | ROCK1 (0.44) | LCKMKNK1ROCK1MAPTMKNK2 | |
| SCHEMBL7016970 | 0.81 | MKNK1 (0.52) | LCKMKNK1ROCK1MAPTMKNK2 | |
| SCHEMBL7492144 | 0.79 | ROCK1 (0.39) | LCKMKNK1ROCK1MAPTMKNK2 | |
| SCHEMBL7497256 | 0.79 | LCK (0.55) | LCKMKNK1KDRROCK1MAPT | |
| SCHEMBL7021439 | 0.78 | JAK2 (0.53) | MKNK1ROCK1MAPTMKNK2MAP3K14 | |
| SCHEMBL7024738 | 0.78 | ROCK1 (0.62) | LCKMKNK1ROCK1POLBMKNK2 | |
| SCHEMBL7027073 | 0.77 | FGFR1 (0.54) | LCKMKNK1THRBNPSR1MKNK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1194152-A4 | SRC KINASE INHIBITOR COMPOUNDS | MERCK & CO INC (US) | 2002-11-06 | — | — | EP | disclosed |
| EP-1194152-A1 | SRC KINASE INHIBITOR COMPOUNDS | Merck & Co., Inc. (US) | 2002-04-10 | — | — | EP | disclosed |
| US-6316444-B1 | SRC kinase inhibitor compounds | MERCK & CO., INC. | 2001-11-13 | — | — | US | disclosed |
| WO-2001000214-A1 | SRC KINASE INHIBITOR COMPOUNDS | MERCK & CO., INC. (US) | 2001-01-04 | — | — | WO | disclosed |