Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.46 |
| ▸ | HRH3 | Q9Y5N1 | 3/20 | 0.45 |
| ▸ | PPARG | P37231 | 13/20 | 0.44 |
| ▸ | PPARA | Q07869 | 13/20 | 0.44 |
| ▸ | HPGD | P15428 | 1/20 | 0.42 |
| ▸ | PPARD | Q03181 | 2/20 | 0.42 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.42 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7494254 | 1.00 | KDM4E (0.46) | KDM4EHRH3PPARGPPARAHPGD | |
| SCHEMBL5795341 | 0.83 | KDM4E (0.54) | KDM4EHRH3PPARGPPARAHPGD | |
| SCHEMBL7487489 | 0.83 | KDM4E (0.51) | KDM4EHRH3PPARGPPARAHPGD | |
| SCHEMBL7487494 | 0.83 | KDM4E (0.51) | KDM4EHRH3PPARGPPARAHPGD | |
| SCHEMBL10480772 | 0.82 | KDM4E (0.53) | KDM4EHRH3PPARGPPARAHPGD | |
| SCHEMBL7489196 | 0.82 | FFAR1 (0.50) | KDM4EPPARGPPARAPPARDFFAR1 | |
| SCHEMBL10480771 | 0.81 | KDM4E (0.52) | KDM4EHRH3PPARGPPARAHPGD | |
| SCHEMBL14373654 | 0.81 | KDM4E (0.59) | KDM4EHRH3PPARGPPARAHPGD | |
| SCHEMBL7879558 | 0.79 | KDM4E (0.56) | KDM4EHRH3PPARGPPARAHPGD | |
| SCHEMBL13960286 | 0.78 | KDM4E (0.55) | KDM4EPPARGPPARAPPARDFFAR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0643050-B1 | Oxazolidinedione derivatives and their use as hypoglycemic agent | TAKEDA CHEMICAL INDUSTRIES LTD (JP) | 2002-04-10 | — | — | EP | disclosed |
| US-5614544-A | HYPOGLYCEMIC AND HYPOLIPIDEMIC AGENTS | TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) | 1997-03-25 | — | — | US | disclosed |
| EP-0643050-A1 | Oxazolidinedione derivatives and their use as hypoglycemic agent | Takeda Chemical Industries, Ltd. (JP) | 1995-03-15 | — | — | EP | disclosed |