Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.56 |
| ▸ | PPARG | P37231 | 15/20 | 0.52 |
| ▸ | PPARA | Q07869 | 14/20 | 0.52 |
| ▸ | HPGD | P15428 | 1/20 | 0.50 |
| ▸ | PPARD | Q03181 | 5/20 | 0.49 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.49 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14373654 | 0.90 | KDM4E (0.59) | KDM4EPPARGPPARAHPGDPPARD | |
| SCHEMBL13960286 | 0.87 | KDM4E (0.55) | KDM4EPPARGPPARAPPARDFFAR1 | |
| SCHEMBL9128417 | 0.86 | FFAR1 (0.67) | KDM4EPPARGPPARAHPGDFFAR1 | |
| SCHEMBL5795341 | 0.86 | KDM4E (0.54) | KDM4EPPARGPPARAHPGDPPARD | |
| SCHEMBL10480772 | 0.85 | KDM4E (0.53) | KDM4EPPARGPPARAHPGDPPARD | |
| SCHEMBL9128422 | 0.84 | PPARG (0.53) | KDM4EPPARGPPARAHPGDPPARD | |
| SCHEMBL10480771 | 0.84 | KDM4E (0.52) | KDM4EPPARGPPARAHPGDPPARD | |
| SCHEMBL9008052 | 0.83 | KDM4E (0.56) | KDM4EPPARGPPARAHPGDPPARD | |
| SCHEMBL7487494 | 0.83 | KDM4E (0.51) | KDM4EPPARGPPARAHPGDPPARD | |
| SCHEMBL7491201 | 0.83 | FFAR1 (0.53) | KDM4EPPARGPPARAHPGDPPARD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6329408-B1 | HYPOCHOLESTEROLEMIC AGENTS; OPTICALLY PURE | PFIZER INC. | 2001-12-11 | — | — | US | disclosed |
| EP-0595868-B1 | PROCESS FOR THE PREPARATION OF (S)-4-[3-(5-METHYL-2-PHENYL-4-OXAZOLYL)- 1-HYDROXYPROPYL]BROMOBENZENE | PFIZER (US) | 1998-11-25 | — | — | EP | disclosed |
| CN-1030195-C | Hypoglycemic thiazolidinediones and intermediates | PFIZER (US) | 1995-11-01 | — | — | CN | disclosed |