Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GAA | P10253 | 2/20 | 0.48 |
| ▸ | MAPT | P10636 | 2/20 | 0.48 |
| ▸ | P2RX4 | Q99571 | 1/20 | 0.43 |
| ▸ | TDP1 | Q9NUW8 | 3/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.41 |
| ▸ | MEN1 | O00255 | 2/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.40 |
| ▸ | GPR35 | Q9HC97 | 2/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | HTT | P42858 | 1/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.40 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.39 |
| ▸ | XDH | P47989 | 1/20 | 0.39 |
| ▸ | PARP1 | P09874 | 1/20 | 0.37 |
| ▸ | TSHR | P16473 | 3/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.37 |
| ▸ | PTPRC | P08575 | 1/20 | 0.37 |
| ▸ | S100A4 | P26447 | 1/20 | 0.37 |
| ▸ | TDP2 | O95551 | 1/20 | 0.36 |
| ▸ | CASP7 | P55210 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17065875 | 0.88 | ALDH1A1 (0.44) | GAAMAPTP2RX4TDP1ALDH1A1 | |
| SCHEMBL11323233 | 0.85 | GAA (0.52) | GAAMAPTP2RX4TDP1ALDH1A1 | |
| SCHEMBL17065871 | 0.77 | GAA (0.46) | GAAMAPTTDP1ALDH1A1MEN1 | |
| SCHEMBL9149469 | 0.75 | MAPT (0.56) | GAAMAPTP2RX4TDP1ALDH1A1 | |
| SCHEMBL27198984 | 0.75 | ALDH1A1 (0.46) | GAAMAPTTDP1ALDH1A1MEN1 | |
| SCHEMBL30776836 | 0.75 | ALDH1A1 (0.46) | GAAMAPTTDP1ALDH1A1MEN1 | |
| SCHEMBL17950650 | 0.74 | PDK2 (0.46) | GAAMAPTTDP1ALDH1A1MEN1 | |
| SCHEMBL29470924 | 0.74 | PDK2 (0.46) | GAAMAPTTDP1ALDH1A1MEN1 | |
| SCHEMBL17072795 | 0.73 | ALDH1A1 (0.49) | GAAMAPTTDP1ALDH1A1MEN1 | |
| SCHEMBL17065876 | 0.73 | ALDH1A1 (0.49) | GAAMAPTTDP1ALDH1A1MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0679641-B1 | SULFONAMIDE AND SULFONIC ESTER DERIVATIVES EACH HAVING TRICYCLIC HETERO RING | EISAI CO LTD (JP) | 2002-10-02 | — | — | EP | disclosed |
| US-5854274-A | Tricyclic heterocyclic sulfonamide and sulfonic ester derivatives | EISAI CO., LTD. (JP) | 1998-12-29 | — | — | US | disclosed |
| EP-0679641-A1 | SULFONAMIDE AND SULFONIC ESTER DERIVATIVES EACH HAVING TRICYCLIC HETERO RING | Eisai Co., Ltd. (JP) | 1995-11-02 | — | — | EP | disclosed |