Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.50 |
| ▸ | MEN1 | O00255 | 1/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.50 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.49 |
| ▸ | RAB9A | P51151 | 2/20 | 0.49 |
| ▸ | TPSAB1 | Q15661 | 3/20 | 0.48 |
| ▸ | TPSD1 | Q9BZJ3 | 2/20 | 0.48 |
| ▸ | TPSG1 | Q9NRR2 | 2/20 | 0.48 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.48 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.48 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.48 |
| ▸ | POLB | P06746 | 1/20 | 0.47 |
| ▸ | HTT | P42858 | 1/20 | 0.47 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.47 |
| ▸ | NPC1 | O15118 | 1/20 | 0.47 |
| ▸ | NAMPT | P43490 | 1/20 | 0.46 |
| ▸ | ITGB3 | P05106 | 1/20 | 0.45 |
| ▸ | ITGA2B | P08514 | 1/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1313894 | 0.84 | SMN1; SMN2 (0.71) | SMN1; SMN2MEN1KMT2AHSD17B10RAB9A | |
| SCHEMBL29104598 | 0.82 | KMT2A (0.67) | SMN1; SMN2MEN1KMT2ATPSAB1TPSD1 | |
| SCHEMBL27544651 | 0.80 | THRB (0.64) | MEN1KMT2APOLBTDP1THRB | |
| SCHEMBL1678005 | 0.78 | NAMPT (0.51) | RAB9ATPSAB1TDP1NAMPTITGB3 | |
| SCHEMBL1677790 | 0.78 | NAMPT (0.51) | RAB9ATPSAB1TDP1NAMPTITGB3 | |
| SCHEMBL13873511 | 0.77 | HTR2A (0.53) | SMN1; SMN2HSD17B10TDP1NAMPTALDH1A1 | |
| SCHEMBL1677593 | 0.76 | KMT2A (0.60) | SMN1; SMN2MEN1KMT2AHSD17B10TPSAB1 | |
| SCHEMBL334426 | 0.76 | SMN1; SMN2 (0.63) | SMN1; SMN2MEN1KMT2AHSD17B10RAB9A | |
| SCHEMBL311932 | 0.75 | GAA (0.67) | SMN1; SMN2MEN1KMT2ARAB9ATPSAB1 | |
| SCHEMBL31298090 | 0.75 | KDM4E (0.66) | KMT2AHSD17B10TPSAB1HTTALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0934293-A1 | NOVEL COMPOUNDS AND COMPOSITIONS FOR TREATING DISEASES ASSOCIATED WITH TRYPTASE ACTIVITY | ARRIS PHARMACEUTICAL CORPORATION (US) | 1999-08-11 | — | — | EP | disclosed |
| WO-1998004537-A1 | NOVEL COMPOUNDS AND COMPOSITIONS FOR TREATING DISEASES ASSOCIATED WITH TRYPTASE ACTIVITY | ARRIS PHARMACEUTICAL CORPORATION (US) | 1998-02-05 | — | — | WO | disclosed |