Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4A | P27815 | 15/20 | 0.48 |
| ▸ | PDE4B | Q07343 | 15/20 | 0.48 |
| ▸ | PDE4C | Q08493 | 15/20 | 0.48 |
| ▸ | PDE4D | Q08499 | 15/20 | 0.48 |
| ▸ | PDE3B | Q13370 | 8/20 | 0.48 |
| ▸ | PDE3A | Q14432 | 8/20 | 0.48 |
| ▸ | ADORA2A | P29274 | 5/20 | 0.43 |
| ▸ | ADORA1 | P30542 | 5/20 | 0.43 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.43 |
| ▸ | ADORA2B | P29275 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7490709 | 0.90 | PDE4A (0.59) | PDE4APDE4BPDE4CPDE4DPDE3B | |
| SCHEMBL6859886 | 0.81 | PDE4A (0.50) | PDE4APDE4BPDE4CPDE4DPDE3B | |
| SCHEMBL31024298 | 0.80 | PDE4A (0.45) | PDE4APDE4BPDE4CPDE4DPDE3B | |
| SCHEMBL6214177 | 0.80 | PDE4A (0.48) | PDE4APDE4BPDE4CPDE4DPDE3B | |
| Hydrochloric Acid SCHEMBL31024297 | 0.79 | PDE4A (0.44) | PDE4APDE4BPDE4CPDE4DPDE3B | |
| SCHEMBL31745005 | 0.73 | ADORA1 (0.54) | PDE4APDE4BPDE4CPDE4DPDE3B | |
| SCHEMBL24170311 | 0.73 | ADORA2A (0.50) | ADORA2AADORA1ADORA2B | |
| SCHEMBL5065955 | 0.72 | ADORA2A (0.56) | ADORA2AADORA1ADORA2B | |
| SCHEMBL3681452 | 0.71 | ADORA2A (0.81) | PDE4APDE4BPDE4CPDE4DPDE3B | |
| SCHEMBL31744975 | 0.70 | ADORA1 (0.47) | PDE4APDE4BPDE4CPDE4DPDE3B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0915093-B1 | AMIDE DERIVATIVES | OTSUKA PHARMA CO LTD (JP) | 2002-11-27 | — | — | EP | disclosed |
| CN-1066448-C | Amide derivatives | OTSUKA PHARMA CO LTD (JP) | 2001-05-30 | — | — | CN | disclosed |
| US-6166016-A | Amide derivatives | OTSUKA PHARMACEUTICAL FACTORY, INC. (JP) | 2000-12-26 | — | — | US | disclosed |
| CN-1221419-A | Amide derivatives | OTSUKA PHARMA CO LTD (JP) | 1999-06-30 | — | — | CN | disclosed |
| EP-0915093-A1 | AMIDE DERIVATIVES | OTSUKA PHARMACEUTICAL FACTORY, INC. (JP) | 1999-05-12 | — | — | EP | disclosed |