Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4A | P27815 | 15/20 | 0.50 |
| ▸ | PDE4B | Q07343 | 15/20 | 0.50 |
| ▸ | PDE4C | Q08493 | 15/20 | 0.50 |
| ▸ | PDE4D | Q08499 | 15/20 | 0.50 |
| ▸ | PDE3B | Q13370 | 8/20 | 0.49 |
| ▸ | PDE3A | Q14432 | 8/20 | 0.49 |
| ▸ | ADORA2A | P29274 | 4/20 | 0.48 |
| ▸ | ADORA1 | P30542 | 4/20 | 0.48 |
| ▸ | AXL | P30530 | 1/20 | 0.44 |
| ▸ | MKNK1 | Q9BUB5 | 1/20 | 0.44 |
| ▸ | MKNK2 | Q9HBH9 | 1/20 | 0.44 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.44 |
| ▸ | ADORA2B | P29275 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4715461 | 0.86 | ADORA2A (0.62) | PDE4APDE4BPDE4CPDE4DPDE3B | |
| SCHEMBL7495122 | 0.81 | PDE4A (0.48) | PDE4APDE4BPDE4CPDE4DPDE3B | |
| SCHEMBL6214177 | 0.81 | PDE4A (0.48) | PDE4APDE4BPDE4CPDE4DPDE3B | |
| SCHEMBL9263999 | 0.80 | AXL (0.48) | PDE4APDE4BPDE4CPDE4DPDE3B | |
| SCHEMBL2311045 | 0.79 | AXL (0.47) | PDE4APDE4BPDE4CPDE4DPDE3B | |
| SCHEMBL21029948 | 0.75 | ADORA2A (0.46) | PDE4APDE4BPDE4CPDE4DPDE3B | |
| SCHEMBL3681452 | 0.72 | ADORA2A (0.81) | PDE4APDE4BPDE4CPDE4DPDE3B | |
| SCHEMBL7490709 | 0.72 | PDE4A (0.59) | PDE4APDE4BPDE4CPDE4DPDE3B | |
| SCHEMBL5849733 | 0.72 | SELE (0.36) | PDE4APDE4BPDE4CPDE4D | |
| SCHEMBL1367259 | 0.72 | AXL (0.52) | ADORA2AADORA1AXLMKNK1MKNK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6787541-B1 | MOVEMENT DISORDERS, PARKINSON'S DISEASE | VERNALIS RESEARCH LIMITED (GB) | 2004-09-07 | — | — | US | disclosed |
| EP-1192164-A1 | THIENO- AND FUROPYRIMIDINE DERIVATIVES AS A2A-RECEPTOR ANTAGONISTS | VERNALIS RESEARCH LIMITED (GB) | 2002-04-03 | — | — | EP | disclosed |
| WO-2001002409-A1 | THIENO- AND FUROPYRIMIDINE DERIVATIVES AS A2A-RECEPTOR ANTAGONISTS | VERNALIS RESEARCH LIMITED (GB) | 2001-01-11 | — | — | WO | disclosed |