Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 6/20 | 0.55 |
| ▸ | NPC1 | O15118 | 5/20 | 0.55 |
| ▸ | RAB9A | P51151 | 5/20 | 0.55 |
| ▸ | GAA | P10253 | 5/20 | 0.55 |
| ▸ | PKM | P14618 | 3/20 | 0.55 |
| ▸ | TP53 | P04637 | 3/20 | 0.55 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.55 |
| ▸ | SCN4A | P35499 | 2/20 | 0.55 |
| ▸ | LMNA | P02545 | 2/20 | 0.55 |
| ▸ | GMNN | O75496 | 1/20 | 0.55 |
| ▸ | USP2 | O75604 | 1/20 | 0.55 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.55 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.55 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.55 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.55 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.55 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.55 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.55 |
| ▸ | BLM | P54132 | 1/20 | 0.55 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.55 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9517440 | 0.88 | SMN1; SMN2 (0.49) | SMN1; SMN2NPC1RAB9AGAAPKM | |
| SCHEMBL9848729 | 0.80 | NPC1 (0.66) | SMN1; SMN2NPC1RAB9AGAAPKM | |
| SCHEMBL31219323 | 0.78 | SMN1; SMN2 (0.61) | SMN1; SMN2NPC1RAB9AGAAPKM | |
| SCHEMBL14726160 | 0.78 | SMN1; SMN2 (0.61) | SMN1; SMN2NPC1RAB9AGAAPKM | |
| SCHEMBL5028769 | 0.78 | SMN1; SMN2 (0.45) | SMN1; SMN2NPC1RAB9AGAAPKM | |
| SCHEMBL19899946 | 0.77 | APP (0.48) | SMN1; SMN2NPC1RAB9AGAAPKM | |
| SCHEMBL3938450 | 0.76 | PTGS1 (0.50) | SMN1; SMN2NPC1RAB9AGAAPKM | |
| SCHEMBL19900645 | 0.76 | SMN1; SMN2 (0.54) | SMN1; SMN2NPC1RAB9AGAAPKM | |
| SCHEMBL20856609 | 0.75 | SMN1; SMN2 (0.56) | SMN1; SMN2NPC1RAB9AGAAPKM | |
| SCHEMBL22130237 | 0.74 | SMN1; SMN2 (0.56) | SMN1; SMN2NPC1RAB9AGAAPKM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0678022-B1 | APPLICATION OF RILUZOLE AS A RADIORESTORER | RHONE POULENC RORER SA (FR) | 1996-11-13 | — | — | EP | disclosed |
| EP-0678023-B1 | APPLICATION OF RILUZOLE IN THE TREATMENT OF PARKINSON'S DISEASE AND PARKINSONIAN SYNDROMES | RHONE POULENC RORER SA (FR) | 1996-10-23 | — | — | EP | disclosed |
| EP-0678023-A1 | APPLICATION OF RILUZOLE IN THE TREATMENT OF PARKINSON'S DISEASE AND PARKINSONIAN SYNDROMES. | RHONE POULENC RORER SA (FR) | 1995-10-25 | — | — | EP | disclosed |
| EP-0678022-A1 | APPLICATION OF RILUZOLE AS A RADIORESTORER. | RHONE POULENC RORER SA (FR) | 1995-10-25 | — | — | EP | disclosed |
| WO-1994015601-A1 | APPLICATION OF RILUZOLE IN THE TREATMENT OF PARKINSON'S DISEASE AND PARKINSONIAN SYNDROMES | RHONE-POULENC RORER S.A. (FR) | 1994-07-21 | — | — | WO | disclosed |
| WO-1994015600-A1 | APPLICATION OF RILUZOLE AS A RADIORESTORER | RHONE-POULENC RORER S.A. (FR) | 1994-07-21 | — | — | WO | disclosed |