Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM5B | Q9UGL1 | 7/20 | 0.41 |
| ▸ | KDM5A | P29375 | 11/20 | 0.39 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.38 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3699901 | 1.00 | KDM5B (0.41) | KDM5BKDM5ASCN9AEPHX2 | |
| SCHEMBL3688062 | 0.92 | EPHX2 (0.37) | KDM5AEPHX2 | |
| SCHEMBL3790725 | 0.92 | EPHX2 (0.38) | KDM5BKDM5AEPHX2 | |
| SCHEMBL3790727 | 0.92 | EPHX2 (0.38) | KDM5BKDM5AEPHX2 | |
| SCHEMBL3683862 | 0.91 | TYRO3 (0.38) | KDM5ASCN9AEPHX2 | |
| SCHEMBL7500241 | 0.91 | TYRO3 (0.38) | KDM5ASCN9AEPHX2 | |
| SCHEMBL3787870 | 0.89 | TEAD1 (0.41) | EPHX2 | |
| SCHEMBL3787876 | 0.89 | TEAD1 (0.41) | EPHX2 | |
| SCHEMBL3784974 | 0.89 | KMT2A (0.37) | KDM5AEPHX2 | |
| SCHEMBL3784977 | 0.89 | KMT2A (0.37) | KDM5AEPHX2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20120121540-A1 | Certain Nitrogen Containing Bicyclic Chemical Entities For Treating Viral Infections | GLAXOSMITHKLINE LLC | 2012-05-17 | — | — | US | disclosed |
| US-20120121540-A1 | Certain Nitrogen Containing Bicyclic Chemical Entities For Treating Viral Infections | GLAXOSMITHKLINE LLC | 2012-05-17 | — | — | US | disclosed |
| US-20090176778-A1 | Certain nitrogen containing bicyclic chemical entities for treating viral infections | GLAXOSMITHKLINE LLC | 2009-07-09 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120121540-A1 | Certain Nitrogen Containing Bicyclic Chemical Entities For Treating Viral Infections | OAT, HAVCR2, CPS1 | KDM5B 3291/4885KDM5A 3315/4885SCN9A 2892/4885 |
| US-20090176778-A1 | Certain nitrogen containing bicyclic chemical entities for treating viral infections | OAT, HAVCR2, CPS1 | KDM5B 3291/4885KDM5A 3315/4885SCN9A 2892/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.