Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CACNA1B | Q00975 | 6/20 | 0.48 |
| ▸ | BRD4 | O60885 | 3/20 | 0.47 |
| ▸ | MGAT2 | Q10469 | 4/20 | 0.45 |
| ▸ | MGAT1 | P26572 | 2/20 | 0.43 |
| ▸ | MGAT3 | Q09327 | 1/20 | 0.43 |
| ▸ | CACNA1H | O95180 | 4/20 | 0.41 |
| ▸ | PSEN1 | P49768 | 1/20 | 0.41 |
| ▸ | PSEN2 | P49810 | 1/20 | 0.41 |
| ▸ | APH1B | Q8WW43 | 1/20 | 0.41 |
| ▸ | NCSTN | Q92542 | 1/20 | 0.41 |
| ▸ | APH1A | Q96BI3 | 1/20 | 0.41 |
| ▸ | PSENEN | Q9NZ42 | 1/20 | 0.41 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.41 |
| ▸ | LIMK2 | P53671 | 1/20 | 0.41 |
| ▸ | BRD2 | P25440 | 1/20 | 0.40 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.40 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.40 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.40 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.40 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7496800 | 1.00 | CACNA1B (0.48) | CACNA1BBRD4MGAT2MGAT1MGAT3 | |
| SCHEMBL7495974 | 0.96 | CACNA1B (0.54) | CACNA1BBRD4MGAT2MGAT1MGAT3 | |
| SCHEMBL7495963 | 0.96 | CACNA1B (0.54) | CACNA1BBRD4MGAT2MGAT1MGAT3 | |
| SCHEMBL7499109 | 0.89 | MAPT (0.52) | BRD4MGAT2MGAT1MGAT3LMNA | |
| SCHEMBL7499102 | 0.89 | MAPT (0.52) | BRD4MGAT2MGAT1MGAT3LMNA | |
| SCHEMBL7493556 | 0.86 | BRD4 (0.62) | BRD4MGAT2MGAT1MGAT3BRD2 | |
| SCHEMBL7493564 | 0.86 | BRD4 (0.62) | BRD4MGAT2MGAT1MGAT3BRD2 | |
| SCHEMBL7497322 | 0.85 | MGAT2 (0.55) | BRD4MGAT2MGAT1MGAT3BRD2 | |
| SCHEMBL7488835 | 0.85 | MGAT2 (0.55) | BRD4MGAT2MGAT1MGAT3BRD2 | |
| SCHEMBL7494041 | 0.85 | BRD4 (0.45) | BRD4MGAT2MGAT1MGAT3LIMK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1224169-A2 | PRODUCTION OF 5-SUBSTITUTED INDOLINONES AND USE THEREOF AS MEDICAMENTS | Boehringer Ingelheim Pharma KG (DE) | 2002-07-24 | — | — | EP | disclosed |
| WO-2001027080-A2 | 5-SUBSTITUTED INDOLINONES AND USE THEREOF AS KINASE AND CYCLIN/CDK COMPLEX INHIBITORS | BOEHRINGER INGELHEIM PHARMA KG (DE) | 2001-04-19 | — | — | WO | disclosed |