Predicted protein targets (top 1)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CCR5 | P51681 | 20/20 | 0.66 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7500736 | 0.87 | CCR5 (0.65) | CCR5 | |
| SCHEMBL7499530 | 0.83 | CCR5 (0.51) | CCR5 | |
| SCHEMBL7499127 | 0.82 | SMN1; SMN2 (0.50) | CCR5 | |
| SCHEMBL7495059 | 0.81 | CCR5 (0.66) | CCR5 | |
| SCHEMBL7542224 | 0.81 | CCR5 (0.68) | CCR5 | |
| SCHEMBL7544496 | 0.80 | CCR5 (0.48) | CCR5 | |
| SCHEMBL7931947 | 0.79 | CCR5 (1.00) | CCR5 | |
| SCHEMBL7931945 | 0.79 | CCR5 (1.00) | CCR5 | |
| SCHEMBL7503537 | 0.79 | CCR5 (0.44) | CCR5 | |
| SCHEMBL7500050 | 0.79 | KDM1A (0.47) | CCR5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1171122-A4 | PYRROLIDINE MODULATORS OF CHEMOKINE RECEPTOR ACTIVITY | MERCK & CO INC (US) | 2002-05-29 | — | — | EP | disclosed |
| EP-1171122-A1 | PYRROLIDINE MODULATORS OF CHEMOKINE RECEPTOR ACTIVITY | Merck & Co., Inc. (US) | 2002-01-16 | — | — | EP | disclosed |
| US-6248755-B1 | ANTIINFLAMMATORY AGENTS; ANTIALLERGENS; AUTOIMMUNE DISEASES | MERCK & CO., INC. | 2001-06-19 | — | — | US | disclosed |
| WO-2000059502-A1 | PYRROLIDINE MODULATORS OF CHEMOKINE RECEPTOR ACTIVITY | MERCK & CO., INC. (US) | 2000-10-12 | — | — | WO | disclosed |