Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HPGD | P15428 | 1/20 | 0.46 |
| ▸ | ADRB1 | P08588 | 6/20 | 0.41 |
| ▸ | ADRB3 | P13945 | 4/20 | 0.41 |
| ▸ | ADRB2 | P07550 | 3/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | HTR1A | P08908 | 1/20 | 0.38 |
| ▸ | DRD2 | P14416 | 1/20 | 0.38 |
| ▸ | HTR2A | P28223 | 1/20 | 0.38 |
| ▸ | NPC1 | O15118 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7492080 | 1.00 | HPGD (0.46) | HPGDADRB1ADRB3ADRB2MEN1 | |
| SCHEMBL5364474 | 0.84 | HPGD (0.48) | HPGDADRB1ADRB3ADRB2MEN1 | |
| SCHEMBL5365543 | 0.84 | HPGD (0.48) | HPGDADRB1ADRB3ADRB2MEN1 | |
| SCHEMBL1384570 | 0.83 | NPC1 (0.57) | ADRB1ADRB3ADRB2MEN1KMT2A | |
| SCHEMBL1384566 | 0.83 | NPC1 (0.57) | ADRB1ADRB3ADRB2MEN1KMT2A | |
| SCHEMBL7498447 | 0.81 | NPC1 (0.43) | HPGDADRB1ADRB3MEN1KMT2A | |
| SCHEMBL7487764 | 0.81 | MEN1 (0.51) | ADRB1ADRB3ADRB2MEN1KMT2A | |
| SCHEMBL7497593 | 0.81 | KMT2A (0.46) | ADRB3MEN1KMT2AHTR1ADRD2 | |
| SCHEMBL7492086 | 0.81 | KMT2A (0.46) | ADRB3MEN1KMT2AHTR1ADRD2 | |
| SCHEMBL7492083 | 0.81 | KMT2A (0.46) | ADRB3MEN1KMT2AHTR1ADRD2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1216244-A1 | Benzisoxazolyl-, pyridoisoxazolyl- and benzthienyl-phenoxy derivatives useful as D4 antagonists | Aventis Pharmaceuticals Inc. (US) | 2002-06-26 | — | — | EP | disclosed |
| WO-2001019821-A1 | BENZISOXAZOLYL-, PYRIDOISOXAZOLYL- AND BENZTHIENYL-PHENOXY DERIVATIVES USEFUL AS D4 ANTAGONISTS | AVENTIS PHARMACEUTICALS INC. (US) | 2001-03-22 | — | — | WO | disclosed |