Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 16/20 | 1.00 |
| ▸ | ABL1 | P00519 | 5/20 | 1.00 |
| ▸ | ABL2 | P42684 | 2/20 | 1.00 |
| ▸ | ERBB2 | P04626 | 2/20 | 0.65 |
| ▸ | PTK6 | Q13882 | 1/20 | 0.65 |
| ▸ | BRAF | P15056 | 1/20 | 0.63 |
| ▸ | TNNI3K | Q59H18 | 1/20 | 0.63 |
| ▸ | FADS1 | O60427 | 2/20 | 0.61 |
| ▸ | LCK | P06239 | 1/20 | 0.60 |
| ▸ | TTBK1 | Q5TCY1 | 1/20 | 0.59 |
| ▸ | TTBK2 | Q6IQ55 | 1/20 | 0.59 |
| ▸ | PRKCA | P17252 | 3/20 | 0.55 |
| ▸ | SRC | P12931 | 2/20 | 0.55 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.55 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.55 |
| ▸ | CDK1 | P06493 | 1/20 | 0.55 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL7499723 | 0.99 | EGFR (0.97) | EGFRABL1ABL2ERBB2PTK6 | |
| SCHEMBL7497212 | 0.85 | EGFR (0.73) | EGFRABL1ABL2ERBB2PTK6 | |
| SCHEMBL7216425 | 0.84 | EGFR (1.00) | EGFRABL1ABL2ERBB2BRAF | |
| SCHEMBL7222290 | 0.84 | EGFR (1.00) | EGFRABL1ABL2BRAFTNNI3K | |
| Hydrochloric Acid SCHEMBL7217999 | 0.83 | EGFR (0.97) | EGFRABL1ABL2BRAFTNNI3K | |
| SCHEMBL27199972 | 0.81 | EGFR (0.68) | EGFRABL1ABL2ERBB2PTK6 | |
| SCHEMBL29406611 | 0.79 | EGFR (1.00) | EGFRABL1ABL2PRKCA | |
| SCHEMBL2463632 | 0.79 | EGFR (1.00) | EGFRABL1ABL2PRKCA | |
| SCHEMBL2462851 | 0.78 | EGFR (1.00) | EGFRABL1ABL2FADS1TTBK1 | |
| SCHEMBL6882539 | 0.77 | TNNI3K (1.00) | EGFRABL1ABL2BRAFTNNI3K |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0836605-B1 | PYRROLOPYRIMIDINES AND PROCESSES FOR THE PREPARATION THEREOF | NOVARTIS AG (CH) | 2002-02-06 | — | — | EP | disclosed |
| US-6140332-A | Pyrrolopyrimidines and processes for the preparation thereof | NOVARTIS AG (CH) | 2000-10-31 | — | — | US | disclosed |
| EP-0836605-A1 | PYRROLOPYRIMIDINES AND PROCESSES FOR THE PREPARATION THEREOF | Novartis AG (CH) | 1998-04-22 | — | — | EP | disclosed |
| WO-1997002266-A1 | PYRROLOPYRIMIDINES AND PROCESSES FOR THE PREPARATION THEREOF | NOVARTIS AG (CH) | 1997-01-23 | — | — | WO | disclosed |