Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 14/20 | 1.00 |
| ▸ | ABL1 | P00519 | 4/20 | 0.72 |
| ▸ | ABL2 | P42684 | 2/20 | 0.72 |
| ▸ | TNNI3K | Q59H18 | 2/20 | 0.62 |
| ▸ | BRAF | P15056 | 1/20 | 0.62 |
| ▸ | PRKCA | P17252 | 2/20 | 0.61 |
| ▸ | DAPK3 | O43293 | 1/20 | 0.54 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.54 |
| ▸ | ERBB2 | P04626 | 1/20 | 0.54 |
| ▸ | PIM1 | P11309 | 1/20 | 0.54 |
| ▸ | PRKACA | P17612 | 1/20 | 0.54 |
| ▸ | LTK | P29376 | 1/20 | 0.54 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.54 |
| ▸ | CSNK1A1 | P48729 | 1/20 | 0.54 |
| ▸ | RPS6KA3 | P51812 | 1/20 | 0.54 |
| ▸ | LIMK1 | P53667 | 1/20 | 0.54 |
| ▸ | MAP2K1 | Q02750 | 1/20 | 0.54 |
| ▸ | ACVR1 | Q04771 | 1/20 | 0.54 |
| ▸ | TYRO3 | Q06418 | 1/20 | 0.54 |
| ▸ | MAP4K2 | Q12851 | 1/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7497652 | 0.84 | EGFR (1.00) | EGFRABL1ABL2TNNI3KBRAF | |
| SCHEMBL7222290 | 0.84 | EGFR (1.00) | EGFRABL1ABL2TNNI3KBRAF | |
| Hydrochloric Acid SCHEMBL7499723 | 0.83 | EGFR (0.97) | EGFRABL1ABL2TNNI3KBRAF | |
| Hydrochloric Acid SCHEMBL7217999 | 0.83 | EGFR (0.97) | EGFRABL1ABL2TNNI3KBRAF | |
| SCHEMBL7215763 | 0.78 | EGFR (0.97) | EGFRABL1DAPK3MAP4K4ERBB2 | |
| SCHEMBL6882539 | 0.78 | TNNI3K (1.00) | EGFRABL1ABL2TNNI3KBRAF | |
| Hydrochloric Acid SCHEMBL7215860 | 0.77 | EGFR (1.00) | EGFRABL1DAPK3MAP4K4ERBB2 | |
| SCHEMBL2461344 | 0.76 | EGFR (1.00) | EGFRABL1ABL2PRKCA | |
| SCHEMBL30159366 | 0.74 | LIMK1 (0.59) | EGFRABL1ABL2ERBB2LIMK1 | |
| SCHEMBL3473013 | 0.74 | LIMK1 (0.59) | EGFRABL1ABL2ERBB2LIMK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6596726-B1 | Method of inhibiting epidermal growth factor by treating, with an effective inhibiting amount, a mammal, in need thereof inhibit the epidermal growth factor receptor and related receptors and, in particular, their tyrosine kinase enzyme | WARNER LAMBERT COMPANY | 2003-07-22 | — | — | US | disclosed |
| EP-0741711-A1 | TRICYCLIC COMPOUNDS CAPABLE OF INHIBITING TYROSINE KINASES OF THE EPIDERMAL GROWTH FACTOR RECEPTOR FAMILY | WARNER-LAMBERT COMPANY (US) | 1996-11-13 | — | — | EP | disclosed |
| WO-1995019970-A1 | TRICYCLIC COMPOUNDS CAPABLE OF INHIBITING TYROSINE KINASES OF THE EPIDERMAL GROWTH FACTOR RECEPTOR FAMILY | WARNER-LAMBERT COMPANY (US) | 1995-07-27 | — | — | WO | disclosed |