Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 4/20 | 0.54 |
| ▸ | FADS1 | O60427 | 4/20 | 0.54 |
| ▸ | PDE5A | O76074 | 3/20 | 0.54 |
| ▸ | ABCG2 | Q9UNQ0 | 2/20 | 0.54 |
| ▸ | LCK | P06239 | 1/20 | 0.53 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.50 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.50 |
| ▸ | NPC1 | O15118 | 1/20 | 0.50 |
| ▸ | RAB9A | P51151 | 1/20 | 0.50 |
| ▸ | MEN1 | O00255 | 1/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.49 |
| ▸ | BRAF | P15056 | 1/20 | 0.48 |
| ▸ | ABL1 | P00519 | 1/20 | 0.46 |
| ▸ | ABL2 | P42684 | 1/20 | 0.46 |
| ▸ | TTBK1 | Q5TCY1 | 1/20 | 0.46 |
| ▸ | TTBK2 | Q6IQ55 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.46 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.46 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.46 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL7499724 | 0.99 | EGFR (0.55) | EGFRFADS1PDE5AABCG2LCK | |
| SCHEMBL7216427 | 0.87 | NPY5R (0.47) | EGFRPDE5AABCG2KDM4ESMN1; SMN2 | |
| SCHEMBL7222295 | 0.85 | EGFR (0.54) | EGFRABCG2BRAF | |
| Hydrochloric Acid SCHEMBL7218002 | 0.84 | EGFR (0.53) | EGFRABCG2BRAF | |
| SCHEMBL19261422 | 0.74 | PDE5A (0.70) | EGFRFADS1PDE5AABCG2LCK | |
| SCHEMBL4740823 | 0.73 | PDE5A (0.72) | EGFRFADS1PDE5AABCG2LCK | |
| SCHEMBL2389719 | 0.72 | GUSB (0.43) | KDM4ESMN1; SMN2NPC1RAB9AMEN1 | |
| SCHEMBL17432159 | 0.72 | MEN1 (0.79) | EGFRFADS1PDE5AABCG2LCK | |
| SCHEMBL7494318 | 0.71 | EGFR (0.49) | EGFRFADS1PDE5AABCG2LCK | |
| Hydrochloric Acid SCHEMBL7218019 | 0.71 | GUSB (0.42) | KDM4ESMN1; SMN2NPC1RAB9AMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0836605-B1 | PYRROLOPYRIMIDINES AND PROCESSES FOR THE PREPARATION THEREOF | NOVARTIS AG (CH) | 2002-02-06 | — | — | EP | disclosed |
| US-6140332-A | Pyrrolopyrimidines and processes for the preparation thereof | NOVARTIS AG (CH) | 2000-10-31 | — | — | US | disclosed |
| EP-0836605-A1 | PYRROLOPYRIMIDINES AND PROCESSES FOR THE PREPARATION THEREOF | Novartis AG (CH) | 1998-04-22 | — | — | EP | disclosed |
| WO-1997002266-A1 | PYRROLOPYRIMIDINES AND PROCESSES FOR THE PREPARATION THEREOF | NOVARTIS AG (CH) | 1997-01-23 | — | — | WO | disclosed |