Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 11/20 | 0.54 |
| ▸ | ABCG2 | Q9UNQ0 | 3/20 | 0.54 |
| ▸ | ABCB1 | P08183 | 2/20 | 0.54 |
| ▸ | FBP1 | P09467 | 2/20 | 0.49 |
| ▸ | EPHB2 | P29323 | 1/20 | 0.49 |
| ▸ | MKNK1 | Q9BUB5 | 1/20 | 0.49 |
| ▸ | BRAF | P15056 | 1/20 | 0.48 |
| ▸ | AURKA | O14965 | 1/20 | 0.46 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.46 |
| ▸ | INCENP | Q9NQS7 | 1/20 | 0.46 |
| ▸ | ABCC1 | P33527 | 1/20 | 0.46 |
| ▸ | EPAS1 | Q99814 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL7218002 | 0.99 | EGFR (0.53) | EGFRABCG2ABCB1FBP1EPHB2 | |
| SCHEMBL7216427 | 0.87 | NPY5R (0.47) | EGFRABCG2AURKB | |
| SCHEMBL7497657 | 0.85 | EGFR (0.54) | EGFRABCG2BRAF | |
| Hydrochloric Acid SCHEMBL7499724 | 0.84 | EGFR (0.55) | EGFRABCG2BRAF | |
| SCHEMBL7215504 | 0.83 | EGFR (0.60) | EGFRABCG2FBP1EPHB2MKNK1 | |
| SCHEMBL7221486 | 0.81 | EGFR (0.54) | EGFRABCG2ABCB1FBP1EPHB2 | |
| SCHEMBL7215637 | 0.80 | ABCG2 (0.53) | EGFRABCG2ABCB1FBP1ABCC1 | |
| Hydrochloric Acid SCHEMBL7215768 | 0.80 | EGFR (0.53) | EGFRABCG2ABCB1FBP1EPHB2 | |
| SCHEMBL2992623 | 0.71 | EGFR (1.00) | EGFRABCG2FBP1EPHB2AURKB | |
| SCHEMBL6679950 | 0.70 | LMNA (0.41) | EGFRABCG2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6596726-B1 | Method of inhibiting epidermal growth factor by treating, with an effective inhibiting amount, a mammal, in need thereof inhibit the epidermal growth factor receptor and related receptors and, in particular, their tyrosine kinase enzyme | WARNER LAMBERT COMPANY | 2003-07-22 | — | — | US | claimed |