Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 3/20 | 0.53 |
| ▸ | PDE4A | P27815 | 3/20 | 0.48 |
| ▸ | PDE4B | Q07343 | 3/20 | 0.48 |
| ▸ | PDE4C | Q08493 | 3/20 | 0.48 |
| ▸ | PDE4D | Q08499 | 3/20 | 0.48 |
| ▸ | TLR7 | Q9NYK1 | 2/20 | 0.47 |
| ▸ | PDE3B | Q13370 | 1/20 | 0.46 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.46 |
| ▸ | KAT2B | Q92831 | 1/20 | 0.40 |
| ▸ | TSHR | P16473 | 2/20 | 0.39 |
| ▸ | PTK2B | Q14289 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.39 |
| ▸ | ATM | Q13315 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.38 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.38 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7090963 | 0.84 | TLR7 (0.47) | LMNAPDE4APDE4BPDE4CPDE4D | |
| SCHEMBL7092868 | 0.82 | TLR7 (0.45) | LMNAPDE4APDE4BPDE4CPDE4D | |
| SCHEMBL7495037 | 0.77 | LMNA (0.48) | LMNAPDE4DALDH1A1SMN1; SMN2L3MBTL1 | |
| SCHEMBL7494395 | 0.76 | CYP1A2 (0.46) | PDE4APDE4BPDE4CPDE4DPDE3B | |
| SCHEMBL4957091 | 0.76 | LMNA (0.53) | LMNAPDE4APDE4BPDE4CPDE4D | |
| SCHEMBL5103773 | 0.75 | PDE4A (0.60) | LMNAPDE4APDE4BPDE4CPDE4D | |
| SCHEMBL7493635 | 0.75 | USP2 (0.49) | LMNATSHRALDH1A1SMN1; SMN2MAPK1 | |
| SCHEMBL13180853 | 0.74 | LMNA (0.70) | LMNAALDH1A1MAPK1MEN1CYP1A2 | |
| SCHEMBL7808088 | 0.72 | PDE5A (0.45) | LMNATSHRPTK2BALDH1A1SMN1; SMN2 | |
| SCHEMBL231476 | 0.71 | CYP1A2 (0.46) | PDE4APDE4BPDE4CPDE4DPDE3B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1015434-B1 | NOVEL PYRIMIDIN-4-ONE AND PYRIMIDIN-4-THIONE AS FUNGICIDE | SYNGENTA PARTICIPATIONS AG (CH) | 2002-04-17 | — | — | EP | disclosed |
| US-6277858-B1 | FOR PROTECTION OF PLANTS AGAINST INFESTATION BY PHYTOPATHOGENIC MICROORGANISMS, I.E., FUNGI | SYNGENTA CROP PROTECTION, INC. | 2001-08-21 | — | — | US | disclosed |
| CN-1270593-A | Pyrimidin-4-one and pyrimidin-4-thione as fungicide | NOVARTIS AG (CH) | 2000-10-18 | — | — | CN | disclosed |
| EP-1015434-A2 | NOVEL PYRIMIDIN-4-ONE AND PYRIMIDIN-4-THIONE AS FUNGICIDE | Novartis AG (CH) | 2000-07-05 | — | — | EP | disclosed |
| WO-1999014202-A2 | NOVEL PYRIMIDIN-4-ONE AND PYRIMIDIN-4-THIONE AS FUNGICIDE | NOVARTIS AG (CH) | 1999-03-25 | — | — | WO | disclosed |