Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GSK3B | P49841 | 8/20 | 0.65 |
| ▸ | PRKCA | P17252 | 6/20 | 0.65 |
| ▸ | CCNE2 | O96020 | 1/20 | 0.53 |
| ▸ | CDK4 | P11802 | 1/20 | 0.53 |
| ▸ | CCND1 | P24385 | 1/20 | 0.53 |
| ▸ | CCNE1 | P24864 | 1/20 | 0.53 |
| ▸ | CDK2 | P24941 | 1/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7502631 | 0.94 | GSK3B (0.70) | GSK3BPRKCACCNE2CDK4CCND1 | |
| SCHEMBL8161651 | 0.88 | GSK3B (0.80) | GSK3BPRKCACCNE2CDK4CCND1 | |
| SCHEMBL7501398 | 0.88 | GSK3B (0.79) | GSK3BPRKCACCNE2CDK4CCND1 | |
| SCHEMBL7502301 | 0.86 | GSK3B (0.80) | GSK3BPRKCACDK4CCND1CDK2 | |
| SCHEMBL7498549 | 0.84 | PRKCA (0.64) | GSK3BPRKCACCNE2CDK4CCND1 | |
| SCHEMBL7498955 | 0.83 | GSK3B (0.72) | GSK3BPRKCACDK4CCND1CDK2 | |
| SCHEMBL7496292 | 0.83 | GSK3B (0.58) | GSK3BPRKCACCNE2CDK4CCND1 | |
| SCHEMBL8161731 | 0.83 | CCNE2 (0.78) | GSK3BCCNE2CDK4CCND1CCNE1 | |
| SCHEMBL7499657 | 0.83 | GSK3B (0.70) | GSK3BPRKCACCNE2CDK4CCND1 | |
| SCHEMBL7507319 | 0.82 | GSK3B (0.60) | GSK3BPRKCACCNE2CDK4CCND1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0915870-B1 | SUBSTITUTED BISINDOLYLMALEIMIDES FOR THE INHIBITION OF CELL PROLIFERATION | HOFFMANN LA ROCHE (CH) | 2002-09-25 | — | — | EP | disclosed |
| US-6228877-B1 | ANTICARCINOGENIC, ANTITUMOR AND ANTIPROLIFERATIVE AGENTS | HOFFMANN-LA ROCHE INC. | 2001-05-08 | — | — | US | disclosed |
| EP-0915870-A1 | SUBSTITUTED BISINDOLYLMALEIMIDES FOR THE INHIBITION OF CELL PROLIFERATION | F. HOFFMANN-LA ROCHE AG (CH) | 1999-05-19 | — | — | EP | disclosed |
| WO-1998004551-A1 | SUBSTITUTED BISINDOLYLMALEIMIDES FOR THE INHIBITION OF CELL PROLIFERATION | F. HOFFMANN-LA ROCHE AG (CH) | 1998-02-05 | — | — | WO | disclosed |