Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CA | P42336 | 12/20 | 0.53 |
| ▸ | MTOR | P42345 | 12/20 | 0.53 |
| ▸ | PIK3CB | P42338 | 2/20 | 0.42 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.42 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.42 |
| ▸ | CSNK2A1 | P68400 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | TP53 | P04637 | 1/20 | 0.39 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.39 |
| ▸ | BRD4 | O60885 | 1/20 | 0.38 |
| ▸ | EP300 | Q09472 | 1/20 | 0.38 |
| ▸ | CREBBP | Q92793 | 1/20 | 0.38 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.38 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.38 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL749918 | 0.93 | PIK3CA (0.54) | PIK3CAMTORPIK3CBPIK3CDPIK3CG | |
| SCHEMBL752836 | 0.89 | PIK3CA (0.57) | PIK3CAMTORPIK3CBPIK3CDPIK3CG | |
| SCHEMBL749846 | 0.86 | PIK3CA (0.54) | PIK3CAMTORPIK3CBPIK3CDPIK3CG | |
| SCHEMBL751576 | 0.85 | PIK3CA (0.54) | PIK3CAMTORPIK3CBPIK3CDPIK3CG | |
| SCHEMBL756457 | 0.84 | PIK3CA (0.56) | PIK3CAMTORCYP1A2CYP2C9CYP2C19 | |
| SCHEMBL751862 | 0.84 | PIK3CA (0.56) | PIK3CAMTORPIK3CBMAPT | |
| SCHEMBL752472 | 0.83 | PIK3CA (0.54) | PIK3CAMTORPIK3CBPIK3CDPIK3CG | |
| SCHEMBL758618 | 0.83 | PIK3CA (0.51) | PIK3CAMTORMAPTCYP2C19 | |
| SCHEMBL756108 | 0.81 | PIK3CA (0.59) | PIK3CAMTORPIK3CBPIK3CDPIK3CG | |
| SCHEMBL11027619 | 0.81 | PIK3CA (0.60) | PIK3CAMTORPIK3CBPIK3CDPIK3CG |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2430013-A1 | HETEROARYL COMPOUNDS AS PIKK INHIBITORS | Amgen, Inc (US) | 2012-03-21 | — | — | EP | claimed |
| WO-2010132598-A1 | HETEROARYL COMPOUNDS AS PIKK INHIBITORS | AMGEN INC. (US) | 2010-11-18 | — | — | WO | claimed |