Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CA | P42336 | 17/20 | 0.54 |
| ▸ | MTOR | P42345 | 15/20 | 0.54 |
| ▸ | PIK3CB | P42338 | 3/20 | 0.37 |
| ▸ | PIK3CD | O00329 | 2/20 | 0.37 |
| ▸ | PIK3CG | P48736 | 2/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL749741 | 0.93 | PIK3CA (0.55) | PIK3CAMTOR | |
| SCHEMBL750340 | 0.89 | PIK3CA (0.58) | PIK3CAMTORPIK3CBPIK3CDPIK3CG | |
| SCHEMBL755730 | 0.88 | PIK3CA (0.57) | PIK3CAMTOR | |
| SCHEMBL751575 | 0.87 | PIK3CA (0.55) | PIK3CAMTORPIK3CBPIK3CDPIK3CG | |
| SCHEMBL749847 | 0.85 | PIK3CA (0.53) | PIK3CAMTORPIK3CBPIK3CDPIK3CG | |
| SCHEMBL751862 | 0.81 | PIK3CA (0.56) | PIK3CAMTORPIK3CB | |
| SCHEMBL758618 | 0.80 | PIK3CA (0.51) | PIK3CAMTOR | |
| SCHEMBL2775861 | 0.79 | PIK3CA (0.56) | PIK3CAMTORPIK3CB | |
| SCHEMBL2773726 | 0.79 | PIK3CA (0.51) | PIK3CAMTOR | |
| SCHEMBL749918 | 0.78 | PIK3CA (0.54) | PIK3CAMTORPIK3CBPIK3CDPIK3CG |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2430013-A1 | HETEROARYL COMPOUNDS AS PIKK INHIBITORS | Amgen, Inc (US) | 2012-03-21 | — | — | EP | claimed |
| WO-2010132598-A1 | HETEROARYL COMPOUNDS AS PIKK INHIBITORS | AMGEN INC. (US) | 2010-11-18 | — | — | WO | claimed |