Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.49 |
| ▸ | TSHR | P16473 | 1/20 | 0.49 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | PKM | P14618 | 1/20 | 0.36 |
| ▸ | TGM2 | P21980 | 3/20 | 0.35 |
| ▸ | SIRT5 | Q9NXA8 | 1/20 | 0.35 |
| ▸ | CA1 | P00915 | 2/20 | 0.34 |
| ▸ | CA2 | P00918 | 2/20 | 0.34 |
| ▸ | FOLH1 | Q04609 | 1/20 | 0.34 |
| ▸ | HDAC4 | P56524 | 2/20 | 0.33 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.33 |
| ▸ | JAK3 | P52333 | 1/20 | 0.33 |
| ▸ | BTK | Q06187 | 1/20 | 0.33 |
| ▸ | CTSK | P43235 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | ITGB3 | P05106 | 1/20 | 0.33 |
| ▸ | ITGA2B | P08514 | 1/20 | 0.33 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.33 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.33 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6565711 | 0.81 | ALDH1A1 (0.56) | ALDH1A1TSHRLMNAPKMSIRT5 | |
| SCHEMBL6563192 | 0.81 | CXCR2 (0.51) | ALDH1A1TSHRSIRT5 | |
| SCHEMBL7663605 | 0.78 | KMT2A (0.40) | TSHRLMNAPKMCA1CA2 | |
| SCHEMBL6563000 | 0.78 | ALDH1A1 (0.54) | ALDH1A1TSHRSIRT5FOLH1HDAC4 | |
| SCHEMBL6565740 | 0.77 | ALDH1A1 (0.55) | ALDH1A1TSHRTGM2SIRT5CA1 | |
| SCHEMBL28941368 | 0.77 | CXCR2 (0.38) | ALDH1A1LMNAPKMKMT2A | |
| SCHEMBL6564159 | 0.74 | ALDH1A1 (0.52) | ALDH1A1TSHRSIRT5CA1CA2 | |
| SCHEMBL6564143 | 0.69 | ALDH1A1 (0.47) | ALDH1A1TSHRCA1CA2HDAC4 | |
| SCHEMBL2533467 | 0.69 | CXCR2 (0.51) | TSHRCA1KMT2A | |
| SCHEMBL3726205 | 0.68 | ALDH1A1 (0.89) | ALDH1A1TSHRLMNATGM2CA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1161232-A4 | HYDROXY DIPHENYL UREA SULFONAMIDES AS IL-8 RECEPTOR ANTAGONISTS | SMITHKLINE BEECHAM CORP (US) | 2002-09-18 | — | — | EP | disclosed |
| EP-1161232-A1 | HYDROXY DIPHENYL UREA SULFONAMIDES AS IL-8 RECEPTOR ANTAGONISTS | SmithKline Beecham Corporation (US) | 2001-12-12 | — | — | EP | disclosed |
| WO-2000035442-A1 | HYDROXY DIPHENYL UREA SULFONAMIDES AS IL-8 RECEPTOR ANTAGONISTS | SMITHKLINE BEECHAM CORPORATION (US) | 2000-06-22 | — | — | WO | disclosed |