SCHEMBL7498580

SCHEMBL7498580

O=C(O)COc1cccc2c1CCC(N1CCCC1c1nc(-c3ccccc3)c(-c3ccccc3)o1)C2

nearest known ligand 0.64

Predicted protein targets (top 2)

geneUniProtsupporting neighboursconfidence
PTGIR P43119 20/20 0.64
PTGDR Q13258 9/20 0.48

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7481769 0.91 PTGIR (0.59) PTGIRPTGDR
SCHEMBL7496484 0.87 PTGIR (0.81) PTGIRPTGDR
SCHEMBL7491137 0.86 PTGIR (0.77) PTGIRPTGDR
SCHEMBL7487580 0.85 PTGIR (0.86) PTGIRPTGDR
SCHEMBL7494747 0.85 PTGIR (0.86) PTGIRPTGDR
SCHEMBL7491539 0.85 PTGIR (0.86) PTGIRPTGDR
SCHEMBL7958868 0.85 PTGIR (0.86) PTGIRPTGDR
SCHEMBL6612770 0.85 PTGIR (0.86) PTGIRPTGDR
SCHEMBL7491325 0.84 PTGIR (0.82) PTGIRPTGDR
SCHEMBL7500464 0.84 PTGIR (0.69) PTGIRPTGDR

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1213285-A2 4,5-dipheny-oxazole derivatives and their use as platelet aggregation inhibitors FUJISAWA PHARMACEUTICAL CO., LTD. (JP) 2002-06-12 EP disclosed
US-6300344-B1 FOR THERAPEUTIC AND/OR PROPHYLACTIC TREATMENT OF ARTERIAL OBSTRUCTION, CEREBROVASCULAR DISEASE, HEPATIC CIRRHOSIS, ARTERIOSCLEROSIS, ISCHEMIC HEART DISEASE, RESTENOSIS AFTER PERCUTANEOUS TRANSLUMINAL CORONARY ANGIOPLASTY, HYPERTENSION FUJISAWA PHARMACEUTICAL CO., LTD. (JP) 2001-10-09 US disclosed
US-5972965-A USEFUL FOR INHIBITION OF PLATELET AGGREGATION, VASODILATION, ANTIHYPERTENSIVE ACTIVITY AND PROSTAGLANDIN AGONIST FUJISAWA PHARMACEUTICAL CO., LTD. (JP) 1999-10-26 US disclosed
WO-1997003973-A1 4,5-DIARYL OXAZOLE DERIVATIVES FUJISAWA PHARMACEUTICAL CO., LTD. (JP) 1997-02-06 WO disclosed