Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ITGB3 | P05106 | 13/20 | 0.69 |
| ▸ | ITGAV | P06756 | 13/20 | 0.69 |
| ▸ | ITGA2B | P08514 | 13/20 | 0.69 |
| ▸ | ITGB1 | P05556 | 5/20 | 0.52 |
| ▸ | ITGB5 | P18084 | 5/20 | 0.52 |
| ▸ | PKM | P14618 | 1/20 | 0.51 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.45 |
| ▸ | APP | P05067 | 1/20 | 0.42 |
| ▸ | KCNK3 | O14649 | 1/20 | 0.42 |
| ▸ | KCNK9 | Q9NPC2 | 1/20 | 0.42 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.42 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.42 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.42 |
| ▸ | PARP1 | P09874 | 1/20 | 0.41 |
| ▸ | PARP15 | Q460N3 | 1/20 | 0.41 |
| ▸ | PARP14 | Q460N5 | 1/20 | 0.41 |
| ▸ | PARP10 | Q53GL7 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7499768 | 0.87 | ITGB3 (0.68) | ITGB3ITGAVITGA2BITGB1ITGB5 | |
| SCHEMBL7501753 | 0.86 | ITGB3 (0.67) | ITGB3ITGAVITGA2BITGB1ITGB5 | |
| SCHEMBL7502133 | 0.85 | ITGB3 (0.68) | ITGB3ITGAVITGA2BITGB1ITGB5 | |
| SCHEMBL7502905 | 0.85 | ITGB3 (0.68) | ITGB3ITGAVITGA2BITGB1ITGB5 | |
| SCHEMBL7500870 | 0.85 | ITGB3 (0.68) | ITGB3ITGAVITGA2BITGB1ITGB5 | |
| SCHEMBL7507092 | 0.85 | ITGB3 (0.68) | ITGB3ITGAVITGA2BITGB1ITGB5 | |
| SCHEMBL7504207 | 0.83 | ITGB3 (0.69) | ITGB3ITGAVITGA2BITGB1ITGB5 | |
| SCHEMBL7504211 | 0.83 | ITGB3 (0.69) | ITGB3ITGAVITGA2BITGB1ITGB5 | |
| SCHEMBL7496697 | 0.82 | ITGB3 (0.69) | ITGB3ITGAVITGA2BITGB1ITGB5 | |
| SCHEMBL7496705 | 0.82 | ITGB3 (0.69) | ITGB3ITGAVITGA2BITGB1ITGB5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0894084-B1 | CINNAMIC ACID DERIVATIVES AND THEIR USE AS INTEGRIN ANTAGONISTS | SEARLE & CO (US) | 2002-06-26 | — | — | EP | claimed |
| EP-0894084-B1 | CINNAMIC ACID DERIVATIVES AND THEIR USE AS INTEGRIN ANTAGONISTS | SEARLE & CO (US) | 2002-06-26 | — | — | EP | disclosed |