SCHEMBL7499146

SCHEMBL7499146

OCC(F)(F)OCc1ccccn1

nearest known ligand 0.43

Predicted protein targets (top 18)

geneUniProtsupporting neighboursconfidence
SMN1; SMN2 Q16637 5/20 0.43
NPC1 O15118 2/20 0.43
RAB9A P51151 2/20 0.43
LMNA P02545 1/20 0.43
PARP10 Q53GL7 1/20 0.43
SYK P43405 3/20 0.42
KDM4E B2RXH2 1/20 0.41
ALDH1A1 P00352 1/20 0.41
AURKB Q96GD4 2/20 0.40
INCENP Q9NQS7 2/20 0.40
HRH1 P35367 1/20 0.40
FDPS P14324 1/20 0.40
ABCB1 P08183 1/20 0.40
HTR1A P08908 1/20 0.40
DRD2 P14416 1/20 0.40
MAPT P10636 1/20 0.39
LIN28A Q9H9Z2 1/20 0.39
TDP1 Q9NUW8 1/20 0.39

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL10263667 0.82 SYK (0.43) SMN1; SMN2NPC1RAB9ALMNAPARP10
SCHEMBL3435909 0.78 SYK (0.47) SMN1; SMN2NPC1RAB9ALMNASYK
SCHEMBL10202885 0.75 SYK (0.44) SMN1; SMN2NPC1RAB9ALMNAPARP10
SCHEMBL31306443 0.74 SYK (0.49) PARP10SYKAURKBINCENPABCB1
SCHEMBL9944264 0.73 SYK (0.46) SMN1; SMN2NPC1RAB9ALMNAPARP10
SCHEMBL27607904 0.73 SMN1; SMN2 (0.47) SMN1; SMN2NPC1RAB9ALMNAPARP10
SCHEMBL874832 0.73 SMN1; SMN2 (0.42) SMN1; SMN2NPC1RAB9ALMNAPARP10
SCHEMBL27462504 0.72
SCHEMBL27762371 0.72
SCHEMBL493397 0.72 HRH1 (0.52) SMN1; SMN2NPC1RAB9ALMNAPARP10

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1173170-A4 PYRROLIDINE MODULATORS OF CHEMOKINE RECEPTOR ACTIVITY MERCK & CO INC (US) 2002-05-29 EP disclosed
EP-1192133-A1 N-CYCLOPENTYL MODULATORS OF CHEMOKINE RECEPTOR ACTIVITY Merck & Co., Inc. (US) 2002-04-03 EP disclosed
EP-1173170-A1 PYRROLIDINE MODULATORS OF CHEMOKINE RECEPTOR ACTIVITY Merck & Co., Inc. (US) 2002-01-23 EP disclosed
WO-2000076972-A1 N-CYCLOPENTYL MODULATORS OF CHEMOKINE RECEPTOR ACTIVITY MERCK & CO., INC. (US) 2000-12-21 WO disclosed
WO-2000076514-A1 CYCLOPENTYL MODULATORS OF CHEMOKINE RECEPTOR ACTIVITY MERCK & CO., INC. (US) 2000-12-21 WO disclosed
WO-2000059503-A1 PYRROLIDINE MODULATORS OF CHEMOKINE RECEPTOR ACTIVITY MERCK & CO., INC. (US) 2000-10-12 WO disclosed