SCHEMBL493397

SCHEMBL493397

c1ccc(COCc2ccccn2)nc1

nearest known ligand 0.56

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
HRH1 P35367 1/20 0.52
SMN1; SMN2 Q16637 4/20 0.52
ALDH1A1 P00352 2/20 0.52
KDM4E B2RXH2 1/20 0.52
MAPT P10636 1/20 0.50
LIN28A Q9H9Z2 1/20 0.50
TDP1 Q9NUW8 1/20 0.50
LMNA P02545 2/20 0.49
NPC1 O15118 1/20 0.49
RAB9A P51151 1/20 0.49
ABCB1 P08183 1/20 0.49
HTR1A P08908 1/20 0.49
DRD2 P14416 1/20 0.49
PARP10 Q53GL7 1/20 0.49
SYK P43405 3/20 0.47
HRH3 Q9Y5N1 1/20 0.47
MAOA P21397 1/20 0.47
MAOB P27338 1/20 0.47
AURKB Q96GD4 1/20 0.46
INCENP Q9NQS7 1/20 0.46

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Hydrochloric Acid SCHEMBL27710379 0.98 SMN1; SMN2 (0.50) HRH1SMN1; SMN2ALDH1A1KDM4EMAPT
SCHEMBL9673277 0.89 TSHR (0.60) HRH1SMN1; SMN2ALDH1A1KDM4EMAPT
SCHEMBL2128010 0.87 SMN1; SMN2 (0.46) HRH1SMN1; SMN2ALDH1A1KDM4EMAPT
SCHEMBL27607904 0.87 SMN1; SMN2 (0.47) HRH1SMN1; SMN2ALDH1A1KDM4EMAPT
SCHEMBL28304769 0.87 HRH1 (0.55) HRH1SMN1; SMN2ALDH1A1KDM4EMAPT
SCHEMBL3432856 0.87 SYK (0.46) HRH1SMN1; SMN2ALDH1A1KDM4EMAPT
Hydrochloric Acid SCHEMBL17654896 0.85 ALDH1A1 (0.47) HRH1SMN1; SMN2ALDH1A1KDM4EMAPT
SCHEMBL10263927 0.83 KDM4E (0.45) HRH1SMN1; SMN2ALDH1A1KDM4ELMNA
SCHEMBL8904860 0.83 SMN1; SMN2 (0.47) HRH1SMN1; SMN2ALDH1A1KDM4EMAPT
SCHEMBL19306253 0.83 SMN1; SMN2 (0.45) HRH1SMN1; SMN2ALDH1A1KDM4EMAPT

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 199 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-116148398-A Method for detecting trace chemical hazard in fat-rich food 北京市疾病预防控制中心 2023-05-23 CN claimed
US-20230049294-A1 STEREOSELECTIVE PROCESS OF MANUFACTURE OF PURINE PHOSPHORAMIDATES Atea Pharmaceuticals, Inc. (US) 2023-02-16 US claimed
WO-2021216722-A1 STEREOSELECTIVE PROCESS OF MANUFACTURE OF PURINE PHOSPHORAMIDATES Atea Pharmaceuticals, Inc. (US) 2021-10-28 WO claimed
CN-104530417-A Multifunctional H-type polyethylene glycol derivative and preparation method thereof XIAMEN SINOPEG BIOTECH INC 2015-04-22 CN claimed
CN-104530415-A Hetero-functionalized Y-type polyethylene glycol derivative, preparation method and biologically related substance thereof XIAMEN SINOPEG BIOTECH INC 2015-04-22 CN claimed
CN-104109235-A Mono-functionalized polyethylene glycol with nitrogen atom branched center and its preparation method and biologically-relevant matter XIAMEN SINOPEG BIOTECH CO LTD 2014-10-22 CN claimed
EP-1546162-B1 LUMINESCENCE-BASED METHODS AND PROBES FOR MEASURING CYTOCHROME P450 ACTIVITY PROMEGA CORP (US) 2011-06-22 EP claimed
US-7692022-B2 Using luciferin derivatives for analyzing metabolic activity in animals, cells or in cell-free reaction formulations PROMEGA CORPORATION (US) 2010-04-06 US claimed
EP-1546162-A4 LUMINESCENCE-BASED METHODS AND PROBES FOR MEASURING CYTOCHROME P450 ACTIVITY PROMEGA CORP (US) 2007-07-18 EP claimed
EP-1546162-A2 LUMINESCENCE-BASED METHODS AND PROBES FOR MEASURING CYTOCHROME P450 ACTIVITY PROMEGA CORPORATION (US) 2005-06-29 EP claimed
US-20040171099-A1 Using luciferin derivatives for analyzing metabolic activity in animals, cells or in cell-free reaction formulations PROMEGA CORPORATION 2004-09-02 US claimed
WO-2004027378-A2 LUMINESCENCE-BASED METHODS AND PROBES FOR MEASURING CYTOCHROME P450 ACTIVITY PROMEGA CORPORATION (US) 2004-04-01 WO claimed
US-12551499-B2 Highly active compounds against COVID-19 Atea Pharmaceuticals, Inc. (US) 2026-02-17 US disclosed
EP-4604951-A1 1-(SULFONYL)-N-PHENYLPYRROLIDINE-2-CARBOXAMIDES DERIVATIVES AND USE THEREOF AMIRA THERAPEUTICS, S.L. (ES) 2025-08-27 EP disclosed
CN-113454124-B9 Combination therapies for ARM and natural killer cells 克莱奥药品有限公司 2025-05-30 CN disclosed
CN-113454124-B Combination therapies for ARM and natural killer cells 克莱奥药品有限公司 2025-03-11 CN disclosed
US-4746648-A HYPOTENSIVE, ANTIULCER Sanofi, Institut National de la Recherche Medicale (FR) 1988-05-24 US disclosed
US-4728668-A Aryl and heteroaryl ethers as agents for the treatment of hypersensitive ailments USV PHARMACEUTICAL CORPORATION (US) 1988-03-01 US disclosed
US-4725619-A Aryl and heteroaryl ethers as agents for the treatment of hypersensitive ailments USV PHARMACEUTICAL CORPORATION (US) 1988-02-16 US disclosed
US-4631287-A Aryl and heteroaryl ethers as agents for the treatment of hypersensitive ailments USV PHARMACEUTICAL CORP. (US) 1986-12-23 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-12551499-B2 Highly active compounds against COVID-19 PNP, SLC29A2, MTAP HRH1 3321/4885SMN1; SMN2 1054/4885ALDH1A1 1808/4885
US-20230049294-A1 STEREOSELECTIVE PROCESS OF MANUFACTURE OF PURINE PHOSPHORAMIDATES NUDT1, PNP, ITPA HRH1 1789/4885SMN1; SMN2 1279/4885ALDH1A1 1210/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.