SCHEMBL7499227

SCHEMBL7499227

CCOC(=O)c1ccc(N)c(C)c1F

nearest known ligand 0.56

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 5/20 0.56
HSD17B10 Q99714 3/20 0.56
TSHR P16473 3/20 0.50
LMNA P02545 3/20 0.50
CYP1A2 P05177 1/20 0.50
CYP3A4 P08684 1/20 0.50
MAOA P21397 1/20 0.50
CA12 O43570 3/20 0.46
CA1 P00915 3/20 0.46
CA2 P00918 3/20 0.46
CA7 P43166 3/20 0.46
CA9 Q16790 3/20 0.46
CA14 Q9ULX7 3/20 0.46
MEN1 O00255 2/20 0.44
KMT2A Q03164 2/20 0.44
TP53 P04637 1/20 0.43
HTT P42858 1/20 0.43
NPSR1 Q6W5P4 1/20 0.43
TDP1 Q9NUW8 1/20 0.43
ESR1 P03372 1/20 0.43

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL27556629 0.88 ALDH1A1 (0.57) ALDH1A1HSD17B10TSHRLMNACYP1A2
SCHEMBL55681 0.84 ALDH1A1 (0.61) ALDH1A1HSD17B10TSHRLMNACYP1A2
SCHEMBL16077594 0.83 ALDH1A1 (0.54) ALDH1A1HSD17B10TSHRLMNACYP1A2
SCHEMBL7496480 0.83 TSHR (0.53) ALDH1A1HSD17B10TSHRLMNACA12
SCHEMBL3504104 0.81 ALDH1A1 (0.53) ALDH1A1HSD17B10TSHRLMNACYP1A2
SCHEMBL3676580 0.81 ALDH1A1 (0.53) ALDH1A1HSD17B10TSHRLMNACYP1A2
SCHEMBL20690614 0.80 ALDH1A1 (0.70) ALDH1A1HSD17B10TSHRLMNACYP1A2
SCHEMBL31419520 0.80 ALDH1A1 (0.70) ALDH1A1HSD17B10TSHRLMNACYP1A2
SCHEMBL1958113 0.79 TSHR (0.57) ALDH1A1HSD17B10TSHRLMNACA12
SCHEMBL31535278 0.78 TSHR (0.52) ALDH1A1HSD17B10TSHRLMNACA12

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0882725-B1 QUINOLONECARBOXYLIC ACID DERIVATIVES OR SALTS THEREOF TOYAMA CHEMICAL CO LTD (JP) 2002-12-18 EP disclosed
US-6025370-A METHICILLIN-RESISTANT STAPHYLOCOCCUS AUREUS TOYAMA CHEMICAL CO., LTD. (JP) 2000-02-15 US disclosed
EP-0882725-A1 QUINOLONECARBOXYLIC ACID DERIVATIVES OR SALTS THEREOF TOYAMA CHEMICAL CO., LTD. (JP) 1998-12-09 EP disclosed