Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MKNK2 | Q9HBH9 | 10/20 | 0.47 |
| ▸ | MKNK1 | Q9BUB5 | 7/20 | 0.47 |
| ▸ | LCK | P06239 | 3/20 | 0.45 |
| ▸ | HRH1 | P35367 | 1/20 | 0.45 |
| ▸ | HRH4 | Q9H3N8 | 1/20 | 0.45 |
| ▸ | NPC1 | O15118 | 1/20 | 0.42 |
| ▸ | RAB9A | P51151 | 1/20 | 0.42 |
| ▸ | JAK2 | O60674 | 2/20 | 0.41 |
| ▸ | JAK3 | P52333 | 2/20 | 0.41 |
| ▸ | MEN1 | O00255 | 2/20 | 0.38 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.38 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.38 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.38 |
| ▸ | MAPT | P10636 | 2/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.38 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | USP2 | O75604 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7504938 | 0.93 | MKNK2 (0.47) | MKNK2MKNK1LCKHRH1HRH4 | |
| SCHEMBL7511562 | 0.84 | MKNK2 (0.49) | MKNK2MKNK1LCKHRH1HRH4 | |
| SCHEMBL7021918 | 0.81 | LCK (0.67) | LCKJAK2JAK3 | |
| SCHEMBL7594120 | 0.81 | LCK (0.67) | LCKJAK2JAK3 | |
| SCHEMBL7504052 | 0.81 | MKNK1 (0.67) | MKNK2MKNK1LCKHRH4 | |
| SCHEMBL7499230 | 0.75 | MKNK2 (0.59) | MKNK2MKNK1LCKHRH1HRH4 | |
| SCHEMBL7014492 | 0.74 | LCK (0.67) | MKNK2MKNK1LCKJAK2JAK3 | |
| SCHEMBL7505439 | 0.74 | MKNK2 (0.66) | MKNK2MKNK1LCK | |
| SCHEMBL7505890 | 0.74 | MKNK2 (0.57) | MKNK2MKNK1LCKNPC1RAB9A | |
| SCHEMBL7501973 | 0.73 | MKNK2 (0.67) | MKNK2MKNK1LCKHRH4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1206265-A4 | SRC KINASE INHIBITOR COMPOUNDS | MERCK & CO INC (US) | 2002-08-07 | — | — | EP | disclosed |
| EP-1206265-A1 | SRC KINASE INHIBITOR COMPOUNDS | Merck & Co., Inc. (US) | 2002-05-22 | — | — | EP | disclosed |
| WO-2001000213-A1 | SRC KINASE INHIBITOR COMPOUNDS | MERCK & CO., INC. (US) | 2001-01-04 | — | — | WO | disclosed |