Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MKNK2 | Q9HBH9 | 13/20 | 0.49 |
| ▸ | MKNK1 | Q9BUB5 | 9/20 | 0.49 |
| ▸ | LCK | P06239 | 2/20 | 0.46 |
| ▸ | NPC1 | O15118 | 1/20 | 0.44 |
| ▸ | RAB9A | P51151 | 1/20 | 0.44 |
| ▸ | HRH1 | P35367 | 1/20 | 0.43 |
| ▸ | HRH4 | Q9H3N8 | 1/20 | 0.43 |
| ▸ | SLC2A1 | P11166 | 1/20 | 0.39 |
| ▸ | TP53 | P04637 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7499230 | 0.91 | MKNK2 (0.59) | MKNK2MKNK1LCKHRH1HRH4 | |
| SCHEMBL7499359 | 0.84 | MKNK2 (0.47) | MKNK2MKNK1LCKNPC1RAB9A | |
| SCHEMBL7501017 | 0.82 | MKNK2 (0.54) | MKNK2MKNK1LCKHRH1HRH4 | |
| SCHEMBL7504052 | 0.82 | MKNK1 (0.67) | MKNK2MKNK1LCKHRH4 | |
| SCHEMBL7501256 | 0.80 | MKNK2 (0.45) | MKNK2MKNK1LCKHRH1HRH4 | |
| SCHEMBL7023421 | 0.80 | LCK (0.69) | MKNK2MKNK1LCK | |
| SCHEMBL7500919 | 0.80 | LCK (0.54) | MKNK2MKNK1LCKRAB9AHRH1 | |
| SCHEMBL7509987 | 0.79 | LCK (0.48) | MKNK2MKNK1LCK | |
| SCHEMBL7508884 | 0.78 | MKNK2 (0.58) | MKNK2MKNK1LCK | |
| SCHEMBL7505439 | 0.77 | MKNK2 (0.66) | MKNK2MKNK1LCK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1206265-A4 | SRC KINASE INHIBITOR COMPOUNDS | MERCK & CO INC (US) | 2002-08-07 | — | — | EP | disclosed |
| EP-1206265-A1 | SRC KINASE INHIBITOR COMPOUNDS | Merck & Co., Inc. (US) | 2002-05-22 | — | — | EP | disclosed |
| WO-2001000213-A1 | SRC KINASE INHIBITOR COMPOUNDS | MERCK & CO., INC. (US) | 2001-01-04 | — | — | WO | disclosed |