⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL746872 | 0.82 | — | — | |
| SCHEMBL4937606 | 0.78 | ALDH1A1 (0.39) | — | |
| SCHEMBL191458 | 0.78 | — | — | |
| SCHEMBL28916395 | 0.77 | — | — | |
| SCHEMBL3613683 | 0.73 | — | — | |
| SCHEMBL712276 | 0.73 | — | — | |
| SCHEMBL7505413 | 0.73 | — | — | |
| SCHEMBL5214521 | 0.73 | — | — | |
| SCHEMBL9021441 | 0.73 | — | — | |
| SCHEMBL7297852 | 0.73 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 22 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-107848962-B | Urea derivative or pharmacologically acceptable salt thereof | 杏林制药株式会社 | 2021-04-09 | — | — | CN | disclosed |
| US-10858314-B2 | Urea derivative or pharmacologically acceptable salt thereof | KYORIN PHARMACEUTICAL CO., LTD. (JP) | 2020-12-08 | — | — | US | disclosed |
| EP-3303284-B1 | UREA DERIVATIVE OR PHARMACOLOGICALLY ACCEPTABLE SALT THEREOF | KYORIN SEIYAKU KK (JP) | 2020-04-08 | — | — | EP | disclosed |
| US-20180208552-A1 | UREA DERIVATIVE OR PHARMACOLOGICALLY ACCEPTABLE SALT THEREOF | KYORIN PHARMACEUTICAL CO., LTD. (JP) | 2018-07-26 | — | — | US | disclosed |
| EP-3303284-A1 | UREA DERIVATIVE OR PHARMACOLOGICALLY ACCEPTABLE SALT THEREOF | Kyorin Pharmaceutical Co., Ltd. (JP) | 2018-04-11 | — | — | EP | disclosed |
| WO-2016189877-A1 | UREA DERIVATIVE OR PHARMACOLOGICALLY ACCEPTABLE SALT THEREOF | KYORIN PHARMACEUTICAL CO., LTD. (JP) | 2016-12-01 | — | — | WO | disclosed |
| EP-2430024-A1 | [1,2,4]TRIAZOLO [4,3-B]PYRIDAZINES AS LIGANDS OF THE ANDROGEN RECEPTOR | AstraZeneca AB (SE) | 2012-03-21 | — | — | EP | disclosed |
| WO-2010131022-A1 | [1,2,4] TRIAZOLO [4,3-B] PYRIDAZINES AS LIGANDS OF THE ANDROGEN RECEPTOR | ASTRAZENECA AB (SE) | 2010-11-18 | — | — | WO | disclosed |
| US-20100292222-A1 | CHEMICAL COMPOUNDS 751 | ASTRAZENECA AB (SE) | 2010-11-18 | — | — | US | disclosed |
| CN-100408035-C | Use of valsartan or its metabolite to inhibit platelet aggregation | NOVARTIS AG (CH) | 2008-08-06 | — | — | CN | disclosed |
| US-6777417-B2 | ANTICANCER AGENTS | SUGEN, INC. | 2004-08-17 | — | — | US | disclosed |
| EP-1436259-A1 | 3-(4,5,6,7-TETRAHYDROINDOL-2-YLMETHYLIDIENE)-2-INDOLINONE DERIVATIVES AS KINASE INHIBITORS | Liang, Congxin (US) | 2004-07-14 | — | — | EP | disclosed |
| US-20030119819-A1 | 3-(4,5,6,7-Tetrahydroindol-2-ylmethylidiene-2-indolinone derivatives as kinase inhibitors | SUGEN, INC. | 2003-06-26 | — | — | US | disclosed |
| WO-2003022815-A1 | 3-(4,5,6,7-TETRAHYDROINDOL-2-YLMETHYLIDIENE)-2-INDOLINONE DERIVATIVES AS KINASE INHIBITORS | SUGEN, INC. (US) | 2003-03-20 | — | — | WO | disclosed |
| US-5138029-A | Random repeating units of 3-hydroxybutyrate, 3-hydroxyvalerate and 4-hydroxyvalerate, culture product of alcaligenes | SHOWA DENKO K.K. (JP) | 1992-08-11 | — | — | US | disclosed |
| EP-0466050-A1 | Biodegradable or biocompatible copolymer and process for producing same | SHOWA DENKO KABUSHIKI KAISHA (JP) | 1992-01-15 | — | — | EP | disclosed |
| EP-0069497-B1 | COPOLYESTERS AND PROCESS FOR THEIR PRODUCTION | IMPERIAL CHEMICAL INDUSTRIES PLC (GB) | 1987-04-15 | — | — | EP | disclosed |
| US-4477654-A | POLYLACTONE COPOLYMERS WITH REDUCED CRYSTALLIN= ITY FROM THE CULTURE OF MICROORGANISMS | IMPERIAL CHEMICAL INDUSTRIES PLC (GB) | 1984-10-16 | — | — | US | disclosed |
| EP-0069497-A2 | Copolyesters and process for their production | IMPERIAL CHEMICAL INDUSTRIES PLC (GB) | 1983-01-12 | — | — | EP | disclosed |
| US-3932393-A | 3-Methylenecephalosporins and process for production thereof | ELI LILLY AND COMPANY (US) | 1976-01-13 | — | — | US | disclosed |