SCHEMBL7499647

SCHEMBL7499647

Cc1cc(C)c(Oc2nc(C)cc(N(CCN3CCCC3)C(=O)C(C)C)c2C)c(C)c1

nearest known ligand 0.46

Predicted protein targets (top 2)

geneUniProtsupporting neighboursconfidence
CRHR1 P34998 3/20 0.42
TP53 P04637 1/20 0.36

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL6803463 0.89 CRHR1 (0.42) CRHR1TP53
SCHEMBL6798720 0.86 CRHR1 (0.39) CRHR1TP53
SCHEMBL6804257 0.84 CRHR1 (0.40) CRHR1TP53
SCHEMBL6797817 0.80 CRHR1 (0.41) CRHR1
SCHEMBL6798534 0.80 CRHR1 (0.44) CRHR1
SCHEMBL6799458 0.77 CRHR1 (0.39) CRHR1
SCHEMBL6796031 0.77 CRHR1 (0.39) CRHR1
SCHEMBL6804399 0.70 CRHR1 (0.54) CRHR1
SCHEMBL5845752 0.69 CRHR1 (0.48) CRHR1
SCHEMBL5842998 0.67 CRHR1 (0.56) CRHR1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1263732-A1 CORTICOTROPIN RELEASING FACTOR ANTAGONISTS Pfizer Products Inc. (US) 2002-12-11 EP disclosed
WO-2001053263-A1 CORTICOTROPIN RELEASING FACTOR ANTAGONISTS PFIZER PRODUCTS INC. (US) 2001-07-26 WO disclosed