SCHEMBL7499691

SCHEMBL7499691

CC(C)(C)[Si](C)(C)OCC1CNCC1c1cccc(F)c1

nearest known ligand 0.42

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
HTR2C P28335 3/20 0.42
HTR2A P28223 2/20 0.42
HTR2B P41595 2/20 0.42
RIPK1 Q13546 2/20 0.33
IDO1 P14902 1/20 0.33
TAAR1 Q96RJ0 1/20 0.33
AKT1 P31749 1/20 0.33
ALDH1A1 P00352 2/20 0.32
MAOA P21397 1/20 0.32
MAOB P27338 1/20 0.32
KDM1A O60341 1/20 0.32
RCOR1 Q9UKL0 1/20 0.32
RPS6KB1 P23443 1/20 0.32
TDP1 Q9NUW8 2/20 0.32
CYP3A4 P08684 2/20 0.31
TP53 P04637 1/20 0.31
CYP1A2 P05177 1/20 0.31
CYP2C9 P11712 1/20 0.31
HSD17B10 Q99714 1/20 0.31
NPC1 O15118 1/20 0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL6104505 1.00 HTR2C (0.42) HTR2CHTR2AHTR2BRIPK1IDO1
SCHEMBL4104772 0.86 HTR2C (0.46) HTR2CHTR2AHTR2BAKT1KDM1A
SCHEMBL4110226 0.85 CYP3A4 (0.40) HTR2CHTR2AHTR2BALDH1A1KDM1A
SCHEMBL4104919 0.85 CCR5 (0.43) HTR2CHTR2AHTR2BMAOAMAOB
SCHEMBL4104233 0.85 CCR5 (0.43) HTR2CHTR2AHTR2BMAOAMAOB
SCHEMBL4102126 0.85 CCR5 (0.43) HTR2CHTR2AHTR2BMAOAMAOB
SCHEMBL7496126 0.85 CCR5 (0.43) HTR2CHTR2AHTR2BMAOAMAOB
SCHEMBL5895671 0.80 HTR2A (0.41) HTR2CHTR2AHTR2BRIPK1MAOA
SCHEMBL5895662 0.80 HTR2A (0.41) HTR2CHTR2AHTR2BRIPK1MAOA
SCHEMBL4100379 0.80 CYP2A6 (0.38) ALDH1A1KDM1ACYP3A4

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 11 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-6498161-B1 TREATING INFECTION BY HIV; DELAYING OF THE ONSET OF AIDS; ASTHMA, ALLERGIC RHINITIS, DERMATITIS, CONJUNCTIVITIS, ATHEROSCLEROSIS OR RHEUMATOID ARTHRITIS MERCK & CO., INC. 2002-12-24 US disclosed
US-6399619-B1 PREVENTION AND TREATMENT OF AIDS AND VIRAL INFECTION BY HIV MERCK & CO., INC. 2002-06-04 US disclosed
EP-1173170-A4 PYRROLIDINE MODULATORS OF CHEMOKINE RECEPTOR ACTIVITY MERCK & CO INC (US) 2002-05-29 EP disclosed
EP-1171122-A4 PYRROLIDINE MODULATORS OF CHEMOKINE RECEPTOR ACTIVITY MERCK & CO INC (US) 2002-05-29 EP disclosed
EP-1173170-A1 PYRROLIDINE MODULATORS OF CHEMOKINE RECEPTOR ACTIVITY Merck & Co., Inc. (US) 2002-01-23 EP disclosed
EP-1171122-A1 PYRROLIDINE MODULATORS OF CHEMOKINE RECEPTOR ACTIVITY Merck & Co., Inc. (US) 2002-01-16 EP disclosed
US-6265434-B1 ANTIINFLAMMATORY AGENTS MERCK & CO., INC. 2001-07-24 US disclosed
US-6248755-B1 ANTIINFLAMMATORY AGENTS; ANTIALLERGENS; AUTOIMMUNE DISEASES MERCK & CO., INC. 2001-06-19 US disclosed
WO-2000059503-A1 PYRROLIDINE MODULATORS OF CHEMOKINE RECEPTOR ACTIVITY MERCK & CO., INC. (US) 2000-10-12 WO disclosed
WO-2000059498-A1 PYRROLIDINE MODULATORS OF CHEMOKINE RECEPTOR ACTIVITY MERCK & CO., INC. (US) 2000-10-12 WO disclosed
WO-2000059502-A1 PYRROLIDINE MODULATORS OF CHEMOKINE RECEPTOR ACTIVITY MERCK & CO., INC. (US) 2000-10-12 WO disclosed