Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RPS6KB1 | P23443 | 1/20 | 0.44 |
| ▸ | CSF1R | P07333 | 2/20 | 0.43 |
| ▸ | KIT | P10721 | 14/20 | 0.42 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.42 |
| ▸ | HTT | P42858 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
| ▸ | HRH4 | Q9H3N8 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7499406 | 0.87 | SMN1; SMN2 (0.56) | CSF1RKITROCK1HTTSMN1; SMN2 | |
| SCHEMBL7494890 | 0.87 | KIT (0.46) | CSF1RKITHRH4 | |
| SCHEMBL7495627 | 0.82 | SMN1; SMN2 (0.49) | CSF1RHTTSMN1; SMN2 | |
| SCHEMBL8648167 | 0.80 | ROCK1 (0.47) | RPS6KB1CSF1RROCK1HTTSMN1; SMN2 | |
| SCHEMBL8645966 | 0.80 | ROCK1 (0.47) | RPS6KB1CSF1RROCK1HTTSMN1; SMN2 | |
| Hydrochloric Acid SCHEMBL8649552 | 0.79 | ROCK1 (0.46) | RPS6KB1CSF1RROCK1HTTSMN1; SMN2 | |
| SCHEMBL9115422 | 0.77 | ROCK1 (0.44) | RPS6KB1CSF1RROCK1HTTSMN1; SMN2 | |
| SCHEMBL4338065 | 0.74 | CSF1R (0.52) | CSF1RKITHTT | |
| SCHEMBL7496197 | 0.73 | CSF1R (0.50) | CSF1RKITHTTSMN1; SMN2 | |
| SCHEMBL7021815 | 0.73 | AKT1 (0.56) | RPS6KB1KIT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0888349-B1 | PYRROLOPYRIMIDINES AND PROCESSES FOR THEIR PREPARATION | NOVARTIS AG (CH) | 2002-05-22 | — | — | EP | claimed |
| US-6140317-A | AS INHIBITORS OF PROTEIN KINASES AND HAVE ANTITUMOUR ACTIVITY | NOVARTIS AG (CH) | 2000-10-31 | — | — | US | claimed |
| EP-0888349-A1 | PYRROLOPYRIMIDINES AND PROCESSES FOR THEIR PREPARATION | Novartis AG (CH) | 1999-01-07 | — | — | EP | claimed |
| WO-1997027199-A1 | PYRROLOPYRIMIDINES AND PROCESSES FOR THEIR PREPARATION | NOVARTIS AG (CH) | 1997-07-31 | — | — | WO | claimed |
| EP-0888349-B1 | PYRROLOPYRIMIDINES AND PROCESSES FOR THEIR PREPARATION | NOVARTIS AG (CH) | 2002-05-22 | — | — | EP | disclosed |
| US-6140317-A | AS INHIBITORS OF PROTEIN KINASES AND HAVE ANTITUMOUR ACTIVITY | NOVARTIS AG (CH) | 2000-10-31 | — | — | US | disclosed |
| EP-0888349-A1 | PYRROLOPYRIMIDINES AND PROCESSES FOR THEIR PREPARATION | Novartis AG (CH) | 1999-01-07 | — | — | EP | disclosed |
| WO-1997027199-A1 | PYRROLOPYRIMIDINES AND PROCESSES FOR THEIR PREPARATION | NOVARTIS AG (CH) | 1997-07-31 | — | — | WO | disclosed |