Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 5/20 | 0.64 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.64 |
| ▸ | CTSV | O60911 | 7/20 | 0.57 |
| ▸ | CTSL | P07711 | 7/20 | 0.57 |
| ▸ | AR | P10275 | 2/20 | 0.55 |
| ▸ | SIRT2 | Q8IXJ6 | 1/20 | 0.53 |
| ▸ | MAPT | P10636 | 4/20 | 0.52 |
| ▸ | LMNA | P02545 | 1/20 | 0.52 |
| ▸ | NPC1 | O15118 | 2/20 | 0.50 |
| ▸ | RAB9A | P51151 | 2/20 | 0.50 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.50 |
| ▸ | ATM | Q13315 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2293244 | 0.83 | CXCR2 (0.59) | MEN1KMT2ACTSVCTSLMAPT | |
| SCHEMBL16862294 | 0.82 | MAPT (0.56) | MEN1KMT2ACTSVCTSLMAPT | |
| SCHEMBL3177723 | 0.81 | MEN1 (0.50) | MEN1KMT2ACTSVCTSLAR | |
| SCHEMBL16862346 | 0.80 | KMT2A (0.56) | MEN1KMT2ACTSVCTSLMAPT | |
| SCHEMBL3919788 | 0.79 | MAPK1 (0.63) | MEN1KMT2ACTSVCTSLAR | |
| SCHEMBL10651184 | 0.78 | MAPT (0.51) | MEN1KMT2ACTSVCTSLAR | |
| SCHEMBL16737201 | 0.78 | TSHR (0.50) | MEN1KMT2AMAPTRAB9A | |
| SCHEMBL12086509 | 0.78 | TSHR (0.50) | MEN1KMT2ACTSVCTSLMAPT | |
| SCHEMBL16737117 | 0.78 | MAPT (0.51) | MEN1KMT2AMAPTRAB9ASMN1; SMN2 | |
| SCHEMBL2443092 | 0.78 | TSHR (0.50) | MEN1KMT2ACTSVCTSLMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0679641-B1 | SULFONAMIDE AND SULFONIC ESTER DERIVATIVES EACH HAVING TRICYCLIC HETERO RING | EISAI CO LTD (JP) | 2002-10-02 | — | — | EP | disclosed |
| US-5854274-A | Tricyclic heterocyclic sulfonamide and sulfonic ester derivatives | EISAI CO., LTD. (JP) | 1998-12-29 | — | — | US | disclosed |
| US-5846969-A | Tricyclic heterocyclic sulfonamide and sulfonic ester derivatives | EISAI CO., LTD. (JP) | 1998-12-08 | — | — | US | disclosed |
| US-5834462-A | ANTITUMOR AGENTS; ANTICARCINOGENIC AGENTS PARTICULARLY FOR NASOPHARYNGEL, PULMONARY, INTESTINAL, MAMMARY, UTERUS, GASTRIC, OVARIAN OR LIVER CANCER AND ALSO LEUKEMIA | EISAI CO., LTD. (JP) | 1998-11-10 | — | — | US | disclosed |
| EP-0679641-A1 | SULFONAMIDE AND SULFONIC ESTER DERIVATIVES EACH HAVING TRICYCLIC HETERO RING | Eisai Co., Ltd. (JP) | 1995-11-02 | — | — | EP | disclosed |