Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC8 | Q9BY41 | 2/20 | 0.55 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.55 |
| ▸ | LMNA | P02545 | 2/20 | 0.49 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.48 |
| ▸ | NPC1 | O15118 | 1/20 | 0.47 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.46 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.46 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.46 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.46 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.46 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.46 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.46 |
| ▸ | HDAC9 | Q9UKV0 | 1/20 | 0.46 |
| ▸ | HDAC5 | Q9UQL6 | 1/20 | 0.46 |
| ▸ | FAAH | O00519 | 1/20 | 0.46 |
| ▸ | CTNNB1 | P35222 | 2/20 | 0.45 |
| ▸ | WNT3A | P56704 | 2/20 | 0.45 |
| ▸ | FABP4 | P15090 | 1/20 | 0.44 |
| ▸ | POLB | P06746 | 1/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7505195 | 0.98 | HDAC8 (0.52) | HDAC8HDAC1LMNAPDE4BNPC1 | |
| SCHEMBL27688476 | 0.88 | HDAC8 (0.68) | HDAC8HDAC1LMNAPDE4BNPC1 | |
| SCHEMBL6626765 | 0.86 | HDAC8 (0.66) | HDAC8HDAC1LMNAPDE4BNPC1 | |
| SCHEMBL28023330 | 0.82 | NPC1 (0.54) | NPC1FAAHHPGDKMT2A | |
| 1,2-Dimethoxybenzene SCHEMBL31672175 | 0.81 | LMNA (0.70) | HDAC8HDAC1LMNAPDE4BHDAC3 | |
| SCHEMBL5045736 | 0.80 | NPC1 (0.49) | HDAC8HDAC1LMNANPC1CTNNB1 | |
| SCHEMBL5081630 | 0.78 | CTNNB1 (0.63) | HDAC8HDAC1LMNANPC1CTNNB1 | |
| SCHEMBL30609633 | 0.78 | CTNNB1 (0.63) | HDAC8HDAC1LMNANPC1CTNNB1 | |
| SCHEMBL536179 | 0.77 | HTT (0.62) | HPGDKMT2A | |
| SCHEMBL7499742 | 0.77 | NR1H4 (0.53) | HDAC8HDAC1LMNAPDE4BHDAC3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0721942-B1 | TETRACYCLIC COMPOUND | KYOWA HAKKO KOGYO KK (JP) | 2002-06-05 | — | — | EP | disclosed |
| US-5646283-A | IMMUNOSUPPRESSANTS | KYOWA HAKKO KOGYO CO., LTD. (JP) | 1997-07-08 | — | — | US | disclosed |
| EP-0721942-A1 | NOVEL TETRACYCLIC COMPOUND | KYOWA HAKKO KOGYO CO., LTD. (JP) | 1996-07-17 | — | — | EP | disclosed |