SCHEMBL7499846

SCHEMBL7499846

COC(=O)CC(=O)CC(c1ccccc1)C1OCCO1

nearest known ligand 0.46

Predicted protein targets (top 18)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 4/20 0.41
GLA P06280 1/20 0.41
SMN1; SMN2 Q16637 1/20 0.41
KCNA5 P22460 3/20 0.40
SLC6A3 Q01959 2/20 0.40
HPGD P15428 4/20 0.38
KMT2A Q03164 1/20 0.37
CYP3A4 P08684 2/20 0.37
CYP2D6 P10635 2/20 0.37
CYP2C9 P11712 1/20 0.37
PKM P14618 1/20 0.37
CYP2C19 P33261 1/20 0.37
TDP1 Q9NUW8 1/20 0.36
CYP1A2 P05177 1/20 0.36
TSHR P16473 1/20 0.36
MAPK1 P28482 1/20 0.36
HSD17B10 Q99714 1/20 0.36
GAA P10253 1/20 0.36

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7491789 0.79 ALDH1A1 (0.52) ALDH1A1GLASMN1; SMN2HPGDKMT2A
SCHEMBL11245130 0.73 MGAM (0.33) CYP3A4CYP2C9CYP2C19TSHRHSD17B10
SCHEMBL3834711 0.73 KMT2A (0.46) ALDH1A1SMN1; SMN2KCNA5HPGDKMT2A
SCHEMBL23728071 0.71 ALDH1A1 (0.36) ALDH1A1GLASMN1; SMN2HPGDCYP3A4
Hydrochloric Acid SCHEMBL28325626 0.71 ALDH1A1 (0.47) ALDH1A1SMN1; SMN2KCNA5HPGDKMT2A
SCHEMBL21688300 0.71 FFAR1 (0.56) ALDH1A1GLASMN1; SMN2KCNA5HPGD
SCHEMBL27396478 0.71 ALDH1A1 (0.50) ALDH1A1SMN1; SMN2KCNA5HPGDKMT2A
SCHEMBL14071977 0.68 TACR3 (0.43) ALDH1A1SMN1; SMN2KCNA5KMT2ATSHR
SCHEMBL27797853 0.68 KMT2A (0.58) SMN1; SMN2KCNA5HPGDKMT2ACYP3A4
SCHEMBL2347309 0.67 HPGD (0.57) ALDH1A1KCNA5HPGDKMT2ATSHR

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0882044-B1 1,4-DIHYDROPYRIDINE COMPOUNDS AS BRADYKININ ANTAGONISTS PFIZER (US) 2002-07-17 EP disclosed
CN-1087737-C Dihygropyridine derivatives as bradykinin antagonists PFIZER (US) 2002-07-17 CN disclosed
EP-0777653-B1 DIHYGROPYRIDINE DERIVATIVES AS BRADYKININ ANTAGONISTS PFIZER (US) 2001-08-22 EP disclosed
US-6131226-A 2-SUBSTITUTED,3,5-BIS(METHOXYCARBONYL),4-(2,6-DIHALOPHENYL), 6-(1-((SUBSTITUTED)RING)PIPERAZIN-1,4-YLENE-CARBONYLMETHYL)-1, 4-DIHYDROPYRIDINES; FOR TREATING INFLAMMATION, PAIN, VIRAL INFECTIONS, CARDIOVASCULAR DISEASE, ALLERGIES, ASTHMA PFIZER INC. (US) 2000-10-17 US disclosed
US-5859011-A Dihydropyridine derivatives as bradykinin antagonist PFIZER INC. (US) 1999-01-12 US disclosed
CN-1156449-A Dihygropyridine derivatives as bradykinin antagonists PFIZER (US) 1997-08-06 CN disclosed
EP-0777653-A1 DIHYGROPYRIDINE DERIVATIVES AS BRADYKININ ANTAGONISTS PFIZER INC. (US) 1997-06-11 EP disclosed
WO-1996006082-A1 DIHYDROPYRIDINE DERIVATIVES AS BRADYKININ ANTAGONISTS PFIZER INC. (US) 1996-02-29 WO disclosed
WO-1996006083-A1 2-(PIPERAZINYL-1-CARBONYLMETHYL)-1,4-DIHYDROPYRIDINES AS BRADYKININ ANTAGONISTS PFIZER PHARMACEUTICALS INC. (JP) 1996-02-29 WO disclosed