Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 2/20 | 0.37 |
| ▸ | TP53 | P04637 | 1/20 | 0.37 |
| ▸ | SLC2A4 | P14672 | 2/20 | 0.37 |
| ▸ | SLC2A8 | Q9NY64 | 1/20 | 0.37 |
| ▸ | LPAR1 | Q92633 | 5/20 | 0.36 |
| ▸ | LPAR5 | Q9H1C0 | 3/20 | 0.36 |
| ▸ | LPAR3 | Q9UBY5 | 1/20 | 0.35 |
| ▸ | SLC2A1 | P11166 | 2/20 | 0.34 |
| ▸ | CRHBP | P24387 | 1/20 | 0.34 |
| ▸ | CRHR2 | Q13324 | 1/20 | 0.34 |
| ▸ | MEN1 | O00255 | 2/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.34 |
| ▸ | ESRRG | P62508 | 1/20 | 0.34 |
| ▸ | CA12 | O43570 | 2/20 | 0.33 |
| ▸ | CA1 | P00915 | 2/20 | 0.33 |
| ▸ | CA2 | P00918 | 2/20 | 0.33 |
| ▸ | CA9 | Q16790 | 2/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | MITF | O75030 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL747946 | 0.91 | TP53 (0.40) | MAPTTP53CRHBPCRHR2MEN1 | |
| SCHEMBL748282 | 0.89 | TP53 (0.39) | MAPTTP53SLC2A4SLC2A8LPAR1 | |
| SCHEMBL747155 | 0.88 | TP53 (0.38) | MAPTTP53SLC2A1MEN1KMT2A | |
| SCHEMBL745478 | 0.88 | TP53 (0.38) | MAPTTP53LPAR1LPAR5MEN1 | |
| Hydrochloric Acid SCHEMBL748268 | 0.87 | TP53 (0.38) | MAPTTP53SLC2A1MEN1KMT2A | |
| SCHEMBL746563 | 0.86 | LPAR1 (0.35) | MAPTLPAR1LPAR5LPAR3CRHBP | |
| SCHEMBL746610 | 0.85 | TP53 (0.42) | MAPTTP53LPAR1LPAR5CRHBP | |
| SCHEMBL2385782 | 0.85 | TP53 (0.38) | MAPTTP53CRHBPCRHR2MEN1 | |
| SCHEMBL748509 | 0.84 | LPAR1 (0.43) | MAPTTP53LPAR1LPAR5LPAR3 | |
| SCHEMBL746554 | 0.82 | TP53 (0.34) | MAPTTP53ESRRG |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2049493-B1 | COMPOUNDS SUITABLE AS MODULATORS OF HDL | CADILA HEALTHCARE LTD (IN) | 2012-03-21 | — | — | EP | disclosed |
| US-8022217-B2 | Compounds suitable as modulators of HDL | CADILA HEALTHCARE LIMITED (IN) | 2011-09-20 | — | — | US | disclosed |