Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TP53 | P04637 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | BCL2 | P10415 | 1/20 | 0.36 |
| ▸ | ESRRG | P62508 | 2/20 | 0.35 |
| ▸ | C5AR1 | P21730 | 1/20 | 0.34 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.34 |
| ▸ | PKM | P14618 | 1/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.34 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
| ▸ | GAA | P10253 | 1/20 | 0.34 |
| ▸ | F2 | P00734 | 1/20 | 0.34 |
| ▸ | F10 | P00742 | 1/20 | 0.34 |
| ▸ | F7 | P08709 | 1/20 | 0.34 |
| ▸ | PSEN1 | P49768 | 1/20 | 0.33 |
| ▸ | PSEN2 | P49810 | 1/20 | 0.33 |
| ▸ | APH1B | Q8WW43 | 1/20 | 0.33 |
| ▸ | NCSTN | Q92542 | 1/20 | 0.33 |
| ▸ | APH1A | Q96BI3 | 1/20 | 0.33 |
| ▸ | PSENEN | Q9NZ42 | 1/20 | 0.33 |
| ▸ | SLC2A1 | P11166 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL748268 | 0.99 | TP53 (0.38) | TP53MAPTBCL2ESRRGC5AR1 | |
| SCHEMBL746591 | 0.92 | PARP1 (0.33) | TP53MAPTESRRGC5AR1KDM4E | |
| SCHEMBL747946 | 0.92 | TP53 (0.40) | TP53MAPTESRRGMCHR1PKM | |
| SCHEMBL751012 | 0.92 | PARP1 (0.36) | TP53MAPTBCL2ESRRGC5AR1 | |
| Hydrochloric Acid SCHEMBL747648 | 0.91 | PARP1 (0.36) | TP53MAPTBCL2ESRRGC5AR1 | |
| SCHEMBL747122 | 0.91 | TP53 (0.33) | TP53MAPTBCL2ESRRGC5AR1 | |
| SCHEMBL748282 | 0.90 | TP53 (0.39) | TP53MAPTESRRGMCHR1PKM | |
| Hydrochloric Acid SCHEMBL748492 | 0.90 | TP53 (0.33) | TP53MAPTBCL2ESRRGC5AR1 | |
| SCHEMBL745512 | 0.90 | OPRM1 (0.34) | TP53MAPTESRRGC5AR1PSEN1 | |
| SCHEMBL745478 | 0.90 | TP53 (0.38) | TP53MAPTESRRGMCHR1PKM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2049493-B1 | COMPOUNDS SUITABLE AS MODULATORS OF HDL | CADILA HEALTHCARE LTD (IN) | 2012-03-21 | — | — | EP | claimed |
| US-8022217-B2 | Compounds suitable as modulators of HDL | CADILA HEALTHCARE LIMITED (IN) | 2011-09-20 | — | — | US | claimed |
| EP-2049493-B1 | COMPOUNDS SUITABLE AS MODULATORS OF HDL | CADILA HEALTHCARE LTD (IN) | 2012-03-21 | — | — | EP | disclosed |
| US-8022217-B2 | Compounds suitable as modulators of HDL | CADILA HEALTHCARE LIMITED (IN) | 2011-09-20 | — | — | US | disclosed |