Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGS2 | P35354 | 17/20 | 0.61 |
| ▸ | PTGS1 | P23219 | 4/20 | 0.61 |
| ▸ | NR4A2 | P43354 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7506875 | 0.91 | PTGS2 (0.61) | PTGS2PTGS1NR4A2 | |
| SCHEMBL7503163 | 0.90 | PTGS2 (0.60) | PTGS2PTGS1NR4A2 | |
| SCHEMBL7501153 | 0.90 | PTGS2 (0.60) | PTGS2PTGS1NR4A2 | |
| SCHEMBL215744 | 0.85 | PTGS2 (0.64) | PTGS2PTGS1NR4A2 | |
| SCHEMBL6025799 | 0.82 | PTGS2 (0.68) | PTGS2PTGS1 | |
| SCHEMBL7504636 | 0.81 | PTGS2 (0.58) | PTGS2PTGS1NR4A2 | |
| SCHEMBL7499580 | 0.81 | NR4A2 (0.55) | PTGS2PTGS1NR4A2 | |
| SCHEMBL7500911 | 0.81 | PTGS2 (0.58) | PTGS2PTGS1NR4A2 | |
| SCHEMBL7501262 | 0.81 | NR4A2 (0.55) | PTGS2PTGS1NR4A2 | |
| SCHEMBL7500353 | 0.81 | PTGS2 (0.67) | PTGS2PTGS1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0699192-B1 | SUBSTITUTED OXAZOLYL COMPOUNDS FOR THE TREATMENT OF INFLAMMATION | SEARLE & CO (US) | 2002-07-24 | — | — | EP | claimed |
| EP-0699192-A1 | SUBSTITUTED OXAZOLYL COMPOUNDS FOR THE TREATMENT OF INFLAMMATION | G.D. SEARLE & CO. (US) | 1996-03-06 | — | — | EP | claimed |
| WO-1994027980-A1 | SUBSTITUTED OXAZOLYL COMPOUNDS FOR THE TREATMENT OF INFLAMMATION | G.D. SEARLE & CO. (US) | 1994-12-08 | — | — | WO | claimed |
| EP-0699192-B1 | SUBSTITUTED OXAZOLYL COMPOUNDS FOR THE TREATMENT OF INFLAMMATION | SEARLE & CO (US) | 2002-07-24 | — | — | EP | disclosed |
| US-5719163-A | ARTHRITIS | G.D. SEARLE & CO. (US) | 1998-02-17 | — | — | US | disclosed |
| EP-0699192-A1 | SUBSTITUTED OXAZOLYL COMPOUNDS FOR THE TREATMENT OF INFLAMMATION | G.D. SEARLE & CO. (US) | 1996-03-06 | — | — | EP | disclosed |
| WO-1994027980-A1 | SUBSTITUTED OXAZOLYL COMPOUNDS FOR THE TREATMENT OF INFLAMMATION | G.D. SEARLE & CO. (US) | 1994-12-08 | — | — | WO | disclosed |