Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK14 | Q16539 | 6/20 | 0.62 |
| ▸ | MAPK13 | O15264 | 4/20 | 0.62 |
| ▸ | MAPK12 | P53778 | 4/20 | 0.62 |
| ▸ | MAPK11 | Q15759 | 4/20 | 0.62 |
| ▸ | RAF1 | P04049 | 3/20 | 0.62 |
| ▸ | MAPK9 | P45984 | 3/20 | 0.62 |
| ▸ | EGFR | P00533 | 12/20 | 0.57 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.57 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.51 |
| ▸ | CSNK1A1 | P48729 | 1/20 | 0.48 |
| ▸ | CSNK1D | P48730 | 1/20 | 0.48 |
| ▸ | RPS6KA3 | P51812 | 1/20 | 0.48 |
| ▸ | GSK3B | P49841 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7500317 | 0.83 | MAPK14 (0.61) | MAPK14MAPK13MAPK12MAPK11RAF1 | |
| SCHEMBL4585131 | 0.81 | MAPK14 (0.62) | MAPK14MAPK13MAPK12MAPK11RAF1 | |
| SCHEMBL4586963 | 0.78 | MAPK14 (0.67) | MAPK14MAPK13MAPK12MAPK11RAF1 | |
| SCHEMBL4024638 | 0.78 | MAPK11 (1.00) | MAPK14MAPK13MAPK12MAPK11RAF1 | |
| SCHEMBL4587083 | 0.78 | MAPK11 (1.00) | MAPK14MAPK13MAPK12MAPK11RAF1 | |
| SCHEMBL4583969 | 0.77 | MAPK14 (0.66) | MAPK14MAPK13MAPK12MAPK11RAF1 | |
| SCHEMBL4455230 | 0.77 | MAPK14 (0.92) | MAPK14MAPK13MAPK12MAPK11EGFR | |
| SCHEMBL4583050 | 0.76 | MAPK14 (0.64) | MAPK14MAPK13MAPK12MAPK11RAF1 | |
| SCHEMBL5574428 | 0.75 | MAPK14 (0.69) | MAPK14MAPK13MAPK12MAPK11MAPK9 | |
| SCHEMBL4584991 | 0.75 | MAPK14 (0.59) | MAPK14MAPK13MAPK12MAPK11RAF1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0831830-A4 | IMIDAZOLE COMPOUNDS | SMITHKLINE BEECHAM CORP (US) | 1998-12-02 | — | — | EP | disclosed |
| EP-0831830-A1 | IMIDAZOLE COMPOUNDS | SMITHKLINE BEECHAM CORPORATION (US) | 1998-04-01 | — | — | EP | disclosed |
| WO-1996040143-A1 | IMIDAZOLE COMPOUNDS | SMITHKLINE BEECHAM CORPORATION (US) | 1996-12-19 | — | — | WO | disclosed |