Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BACE1 | P56817 | 1/20 | 0.49 |
| ▸ | PGR | P06401 | 12/20 | 0.40 |
| ▸ | PDE4A | P27815 | 4/20 | 0.38 |
| ▸ | PDE4B | Q07343 | 4/20 | 0.38 |
| ▸ | PDE4C | Q08493 | 4/20 | 0.38 |
| ▸ | PDE4D | Q08499 | 4/20 | 0.38 |
| ▸ | PDE3B | Q13370 | 4/20 | 0.38 |
| ▸ | PDE3A | Q14432 | 4/20 | 0.38 |
| ▸ | HTR2A | P28223 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7499439 | 0.90 | BACE1 (0.47) | BACE1PGRPDE4APDE4BPDE4C | |
| SCHEMBL7504206 | 0.90 | BACE1 (0.47) | BACE1PGRPDE4APDE4BPDE4C | |
| SCHEMBL7493171 | 0.90 | BACE1 (0.47) | BACE1PGRPDE4APDE4BPDE4C | |
| SCHEMBL7501462 | 0.90 | BACE1 (0.49) | BACE1HTR2A | |
| Hydrochloric Acid SCHEMBL7497244 | 0.89 | BACE1 (0.46) | BACE1PGRPDE4APDE4BPDE4C | |
| SCHEMBL12056346 | 0.83 | PGR (0.49) | PGRPDE4APDE4BPDE4CPDE4D | |
| SCHEMBL6637532 | 0.80 | BACE1 (0.52) | BACE1PGRPDE4APDE4BPDE4C | |
| SCHEMBL6637484 | 0.80 | PGR (0.54) | BACE1PGRPDE4APDE4BPDE4C | |
| Hydrochloric Acid SCHEMBL6639312 | 0.78 | BACE1 (0.51) | BACE1PGRPDE4APDE4BPDE4C | |
| Hydrochloric Acid SCHEMBL6639499 | 0.78 | PGR (0.53) | BACE1PGRPDE4APDE4BPDE4C |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1202994-A1 | NEW COMPOUNDS | AstraZeneca AB (SE) | 2002-05-08 | — | — | EP | claimed |
| WO-2001005790-A1 | NEW COMPOUNDS | ASTRAZENECA AB (SE) | 2001-01-25 | — | — | WO | claimed |
| EP-1202994-A1 | NEW COMPOUNDS | AstraZeneca AB (SE) | 2002-05-08 | — | — | EP | disclosed |
| WO-2001005790-A1 | NEW COMPOUNDS | ASTRAZENECA AB (SE) | 2001-01-25 | — | — | WO | disclosed |